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How Exactly does drinking Grapefruit juice interfere with certain medications??
I have asked this question for yrs, and no one, not even the health professionals have given me a good answer!! Hoping someone on this site can help!! Thx Additional Details I will also say that the citrus in Orange juice never is a problem...they just say Grapefruit.
it changes them chemically so that they are not absorbed
Grapefruit juice contains a number of natural substances that suppress an intestinal enzyme (CYP3A) responsible for metabolizing certain medications. This may increase the absorption of some orally administered medications in the bloodstream, and as a result, may increase the effects of the drug and possibly increase the risk of an adverse reaction.
These risks continue for up to 72 hours after consumption.
Note that grapefruit will not interfere with medication administered by injection.
Grapefruit may increase the amount of certain medications in your body.
But chemicals in grapefruit interfere with enzymes that break down certain drugs in your digestive system. This can result in abnormally high blood levels of these drugs and an increased risk of serious side effects.
The exact chemical or chemicals in grapefruit juice that cause this interaction aren't known. But they're present in the pulp and peel of grapefruit as well as in the juice. For this reason, any grapefruit product â€” including dietary supplements that contain grapefruit bioflavonoids â€” can interact with some medications. You may also want to avoid tangelos, a hybrid grapefruit. They may have a similar effect.
Waiting to take medications even up to 24 hours after you drink grapefruit juice will not prevent an interaction.