| zevalin |
Ibritumomab tiuxetan is a type of protein (monoclonal antibody plus a chelator) used, along with another monoclonal antibody (rituximab) and two radioactive pharmaceuticals (In-111 and Y-90); to treat a certain form of cancer (non-Hodgkin s lymphoma).
- Store this product kit refrigerated between 36 and 46 degrees F (2 and 8 degrees C) away from light.
- Do not freeze.
- If overdose is suspected, contact your local poison control center or emergency room immediately.
Oncologie - Zevalin®
- Follow all instructions for proper handling, mixing, and dilution with the correct IV fluids.
- If you have any questions regarding the use of Zevalin, consult the doctor or pharmacist.
- Ibritumomab is not a radioactive chemical by itself.
- There is no risk of radioactive exposure with Zevalin kit until it is combined with the In-111 or Y-90; all radioactive handling precautions should be followed at that time.
- The radioactive medication will be added to Zevalin by a properly-trained medical professional.
- Your doctor may prescribe medications to be taken 30 minutes before Zevalin is given.
- These drugs may help decrease the risk and/or severity of allergic reactions and some side effects.
- After being given another medication (rituximab), Zevalin will be injected into a vein (IV) over 10 minutes exactly as prescribed by the doctor.
- Generally, another rituximab dose is given 7 to 9 days later, followed by Zevalin, given IV over a 10 minute period.
- The dosage is based on your medical condition, response to therapy, and an established dosing guideline.
- Consult your doctor for details.
- Before using, check this product visually for particles or discoloration.
- If either is present, do not use the liquid.
- Learn how to store and discard needles and medical supplies safely.
- Consult your pharmacist.
- Nausea, vomiting, diarrhea, constipation, headache, stomach upset, dizziness, and/or flu-like symptoms (e.g., cough, chills, muscle aches) may occur.
- If any of these effects persist or worsen, notify your doctor promptly.
- Tell your doctor immediately if any of these serious side effects occur: easy bruising or bleeding, persistent sore throat or fever, swelling of the hands/feet/face, unusual tiredness and weakness, loss of appetite, unusual weight loss, pain (e.g., stomach, muscle, back, or joint pain).
- Tell your doctor immediately if any of these unlikely but serious side effects occur: mental/mood changes, unusually fast heartbeat, black stools, coffee-ground vomit, one-sided weakness, vision problems.
- An allergic reaction to Zevalin is unlikely, but seek immediate medical attention if it occurs.
- Symptoms of an allergic reaction may include: rash, itching, swelling, trouble breathing.
- Rarely, Zevalin may cause certain cancers (e.g., AML).
- If you notice other effects not listed above, contact your doctor or pharmacist.
- Tell your doctor your medical history, especially of: blood disorders (e.g., anemia, neutropenia, thrombocytopenia), previous bone marrow therapy (myeloablative), current infections, any allergies.
- Zevalin may make you dizzy; use caution engaging in activities requiring alertness such as driving or using machinery.
- Limit alcoholic beverages.
- Because Zevalin can decrease your immune system function, do not have immunizations/vaccinations without the consent of your doctor and avoid contact with people who have recently received live vaccines (e.g., oral polio vaccine).
- Use caution with sharp objects like safety razors or nail cutters and avoid activities that may increase the chance of getting cut, bruised, or injured.
- Zevalin is not recommended for use during pregnancy; it may cause fetal harm.
- Women of child-bearing age, and men, are recommended to use effective birth control methods during and for up to 1 year after treatment with Zevalin.
- Consult your doctor for more details.
- It is not known whether Zevalin passes into breast milk.
- Because of the potential risk to the infant, breast-feeding while using Zevalin is not recommended.
- If you miss a dose or your dose is stopped, contact your doctor immediately to establish a new dosing schedule.
- Tell your doctor of all prescription and nonprescription medication you may use, especially: blood thinners (e.g., warfarin), drugs that affect the platelets (e.g., aspirin, clopidogrel, ticlopidine, NSAIDs such as ibuprofen), drugs that affect the immune system (e.g., azathioprine, cyclosporine, or corticosteroids such as prednisone).
- Do not start or stop any medicine without doctor or pharmacist approval.