| rapamune |
Rapamune is used to prevent the rejection of transplanted organs (e.g., kidney).
- Store at refrigerator temperature between 36 and 46 degrees F (2 to 8 degrees C) away from light and moisture.
- Once opened, bottles containing Rapamune should be used within 30 days.
- When refrigerated, this product may develop a slight haze.
- If this haze occurs, allow Rapamune to stand at room temperature and shake gently until the haze disappears.
- The haze does not affect the quality of Rapamune.
- If overdose is suspected, contact your local poison control center or emergency room immediately.
- Symptoms of overdose may include irregular heartbeat.
- Take Rapamune by mouth once daily, exactly as prescribed by your doctor.
- The dosage depends on your condition and response to therapy.
- Learn all preparation and usage instructions in the product package.
- Ask your doctor or pharmacist if you have questions about any of the information.
- Mix the prescribed dose of Rapamune with at least two ounces (1/4 cup, 60 ml) of water or orange juice in a plastic or glass container.
- Stir vigorously and drink immediately.
- Refill the container with at least four more ounces (1/2 cup, 120 ml) of water or orange juice, stir vigorously and drink immediately.
- Do not use grapefruit juice to dilute Rapamune.
- Avoid grapefruit juice while using Rapamune unless your doctor specifically instructs you otherwise.
- Rapamune works best when the amount of medicine in your body is kept at a constant level.
- Therefore, take Rapamune at evenly spaced intervals (e.g., every 24 hours) and take Rapamune consistently with or without food.
- Other medications (e.g., antibiotics, other immunosuppressants such as cyclosporine) may be prescribed to prevent infections, and prevent rejection of the transplanted organ.
- Take these medications exactly as prescribed by your doctor.
- If you use certain brands/types of cyclosporine (e.g., Neoral, SangCya), take sirolimus four hours after your dose of cyclosporine.
- Consult your pharmacist for more information.
- If a syringe is used to measure the prescribed dose, use a new syringe for each dose.
- Discard used syringes safely and properly.
- Nausea, diarrhea, or trouble sleeping may occur.
- If any of these effects persist or worsen, notify your doctor promptly.
- Tell your doctor immediately if you have any of these serious side effects: signs of infection such as fever or persistent sore throat, unexplained weight loss, unusual lumps or swollen glands, severe headache, unusual tiredness or weakness, unusual bleeding or bruising, muscle/joint/back pain, unusually fast/slow/irregular pulse, swelling, dizziness, rash.
- Tell your doctor immediately if you have any of these highly unlikely but very serious side effects: a change in the amount of urine.
- If you notice other effects not listed above, contact your doctor or pharmacist.
- Tell your doctor your medical history, including: any allergies, liver problems, high blood levels of cholesterol or triglycerides.
- Rapamune may make you dizzy; use caution engaging in activities requiring alertness such as driving or using machinery.
- Limit alcoholic beverages.
- Do not have immunizations/vaccinations without the consent of your doctor.
- Avoid contact with people who have recently received oral polio vaccine.
- Avoid prolonged sun exposure, tanning booths, or sunlamps.
- Use a sunscreen and wear protective clothing when outdoors.
- Women of childbearing age should use effective birth control methods before starting Rapamune, during the use of Rapamune and for 12 weeks after stopping therapy with Rapamune.
- Consult your doctor or pharmacist for more information.
- Rapamune should be used only when clearly needed during pregnancy.
- Discuss the risks and benefits with your doctor.
- It is not known whether Rapamune is passed into breast milk.
- Because of the potential risk to the infant, breast-feeding while using Rapamune is not recommended.
- Consult your doctor before breast-feeding.
- If you miss a dose, use it as soon as you remember.
- If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.
- Do not double the dose to catch up.
- Tell your doctor of all prescription and nonprescription medication you may use, especially of: drugs for high cholesterol or triglycerides (e.g., lovastatin, atorvastatin, gemfibrozil), calcium-channel blockers (e.g., diltiazem, verapamil, nicardipine), rifamycins (e.g., rifampin, rifabutin), macrolide antibiotics (e.g., clarithromycin, erythromycin), aminoglycoside antibiotics (e.g., gentamicin, tobramycin), antifungal drugs (e.g., ketoconazole, fluconazole, amphotericin B), St John s wort, seizure medications (e.g., phenytoin, phenobarbital, carbamazepine), stomach or ulcer medications (e.g., metoclopramide, cisapride, cimetidine), bromocriptine, danazol, HIV-protease inhibitors (e.g., ritonavir, indinavir).
- Do not start or stop any medicine without doctor or pharmacist approval.