| kaletra |
This combination product is used, along with other medications, to treat Human Immunodeficiency Virus (HIV) infection. These medications belong to a class of drugs called protease inhibitors that block an enzyme needed for HIV to multiply. Decreasing the amount of HIV in your body helps reduce complications, such as infections (opportunistic types such as pneumocystis pneumonia). This product does not cure HIV.
- Store at refrigerated temperature between 36 and 46 degrees F (2 to 8 degrees C) away from light and moisture.
- If stored at room temperature (77 degrees F or 25 degrees C), this product should be used within 2 months.
- Avoid exposure to excessive heat.
- If overdose is suspected, contact your local poison control center or emergency room immediately.
- Symptoms of overdose may include numbness or tingling in the arms, hands, legs, or feet; or change in amount of urine, drowsiness, dizziness, loss of consciousness, or shallow breathing.
- Due to the high alcohol content of lopinavir/ritonavir solution, children accidentally drinking the medication may have a serious, even fatal reaction.
- If accidental ingestion occurs, contact your local poison control center or emergency room.
Kaletra. Zpět AR terapie pro lékaře
- Take this product by mouth, usually twice daily with food; or as directed by your doctor.
- The amount of drug prescribed is based on your medical condition and response to therapy.
- Do not take more or less of Kaletra than prescribed, or stop taking it (or other HIV medicines), even for a brief time, unless directed to do so by your doctor.
- This may cause the amount of the virus to increase or may make the virus more difficult to treat (develop resistance).
- Kaletra works best when the amount of drug in your body is kept at a constant level.
- Therefore, take Kaletra at evenly spaced intervals.
- Find out about other drugs that should not be taken with this product (see Drug Interactions section).
- Diarrhea, headache, nausea, vomiting, drowsiness, dizziness, weakness, rash, and trouble sleeping may occur.
- If these effects persist or worsen, notify your doctor.
- Tell your doctor immediately if you have any of these serious side effects: increased thirst or urination, blurred vision, swelling, stomach pain, chills, joint or muscle pain.
- Tell your doctor immediately if you have any of these unlikely but serious side effects: leg pain, mouth sores, persistent sore throat or fever, weight loss, change in body fat, mental/mood changes, trouble breathing, vision changes, urination problems, decreased sexual ability.
- Tell your doctor immediately if you have any of these highly unlikely but very serious side effects: severe stomach pain, yellowing eyes and skin, dark urine, persistent fever, fatigue.
- Changes in body fat may occur while you are taking Kaletra (e.g., increased fat in the upper back and stomach areas, decreased fat in the arms and legs).
- The cause and long-term effects of these changes are unknown.
- Discuss the risks and benefits of therapy with your doctor, as well as the possible role of exercise to reduce this side effect.
- Kaletra may cause an increase in cholesterol or fat levels (triglycerides) in the blood.
- Cholesterol and triglyceride testing should be done before taking, and occasionally during treatment with, Kaletra.
- Consult your doctor or pharmacist for more information.
- If you notice other effects not listed above, contact your doctor or pharmacist.
- Tell your doctor your medical history, including: any allergies, liver disease, diabetes, pancreatitis, high cholesterol, bleeding problems (e.g., hemophilia), heart disease, other illnesses.
- This product contains a large amount of alcohol and may make you dizzy or drowsy.
- Use caution engaging in activities requiring alertness.
- Limit alcoholic beverages.
- Because this product contains alcohol, severe nausea and vomiting may occur if you are also taking disulfiram or metronidazole with lopinavir/ritonavir solution.
- Consult your doctor or pharmacist before taking either of these medications.
- Caution is advised when using this product in children.
- This product contains a large amount of alcohol and accidental overdose could be serious.
- Kaletra should be used only when clearly needed during pregnancy.
- Discuss the risks and benefits with your doctor.
- It is not known whether Kaletra passes into breast milk.
- Because breast-feeding can transmit HIV, do not breast-feed.
- If you miss a dose, use it as soon as you remember.
- If it is within 2 hours of the next dose, skip the missed dose and resume your usual dosing schedule.
- It is important not to miss doses of Kaletra.
- Remember to refill your medication on time to avoid missing doses.
- Certain medications taken with this product could result in serious, or even fatal, drug interactions.
- Kaletra is not recommended for use with: certain heart medications (e.g., antiarrhythmics such as flecainide, propafenone), astemizole, terfenadine, rifampin, ergot drugs (e.g., dihydroergotamine, ergonovine, methylergonovine, ergotamine), cisapride, certain statins (e.g., lovastatin, simvastatin), St John s wort, pimozide, certain sedatives (e.g., midazolam, triazolam).
- Tell your doctor if you are taking any of these other prescription or non-prescription medications: all other HIV drugs (e.g., efavirenz, nevirapine, amprenavir, zidovudine, abacavir), other heart rhythm medication (e.g., amiodarone, bepridil, lidocaine, quinidine), blood thinners (e.g., warfarin), seizure medication (e.g., phenytoin, carbamazepine, phenobarbital), macrolide antibiotics (e.g., clarithromycin), antifungals (e.g., ketoconazole, itraconazole), rifabutin, atovaquone, calcium channel blockers (e.g., felodipine, nifedipine, nicardipine), dexamethasone, sildenafil, other statins (atorvastatin, cerivastatin), cyclosporine, tacrolimus, rapamycin, methadone, disulfiram, metronidazole, sleeping pills, sedatives, tranquilizers, anti-anxiety drugs, narcotic pain relievers (e.g., codeine), psychiatric medicines, muscle relaxants, antihistamines that cause drowsiness (e.g., diphenhydramine).
- This product may decrease the effectiveness of hormone-type birth control (oral contraceptives).
- Consult your doctor or pharmacist about using other birth control methods.
- Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients.
- Ask you pharmacist about the safe use of those products.
- Do not eat grapefruit or drink grapefruit juice unless your doctor instructs you otherwise.
- If you are taking didanosine in addition to this product, take it one hour before or two hours after Kaletra.
- This product may interfere with certain laboratory tests (e.g., cholesterol, triglycerides, GGT, aminotransferases, glucose).
- Do not start or stop any medicine without doctor or pharmacist approval.