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Drug Guide    T   Tacrolimus

  Prescription drug information   Post your opinion about this drug  

   Tacrolimus

Tacrolimus
IV


Tacrolimus is used with other medications to prevent rejection of a kidney, heart, or liver transplant. The injection form of the medication is used when you cannot take the medication by mouth. As soon possible, your doctor will switch you to the form of this medication that is taken by mouth. This medication belongs to a class of drugs known as immunosuppressants. It works by weakening your body's defense system (immune system) to help your body accept the new organ as if it were your own.This drug may also be used to treat a certain type of bowel condition (severe fulminant Crohn's disease) in patients who have not been successfully treated by the usual treatment.

 
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 Tacrolimus images:

OverviewPhotosHow To UseSide EffectsPrecautionsMissed DoseDrug Interactions
Tacrolimus

Uses
Tacrolimus is used with other medications to prevent rejection of a kidney, heart, or liver transplant. The injection form of the medication is used when you cannot take the medication by mouth. As soon possible, your doctor will switch you to the form of this medication that is taken by mouth. This medication belongs to a class of drugs known as immunosuppressants. It works by weakening your body's defense system (immune system) to help your body accept the new organ as if it were your own.This drug may also be used to treat a certain type of bowel condition (severe fulminant Crohn's disease) in patients who have not been successfully treated by the usual treatment.
Notes
  • Laboratory and/or medical tests (e.g., potassium levels, blood sugar, tacrolimus blood level, kidney/liver function) will be performed periodically to monitor your progress or check for side effects.
  • Consult your doctor for more details.If you have had an organ transplant, it is recommended that you attend a transplant education class or support group.
  • Learn the signs of organ rejection such as tenderness/pain around the transplanted organ, a feeling of being ill, or fever.
  • Tell your doctor immediately if you notice any of these signs.

Storage
  • Store the U.S.
  • product between 41-77 degrees F (5-25 degrees C).Store the Canadian product between 59-77 degrees F (15-25 degrees C).The diluted medication should be stored in a glass or polyethylene container and used or discarded within 24 hours.Keep all medicines away from children and pets.


How To Use
  • This medication is given by injection into a vein by a health care professional.
  • Follow all instructions for proper dilution with the correct IV fluids.
  • Before using, check this product visually for particles or discoloration.
  • If either is present, do not use the liquid.
  • If you have any questions about how to prepare or use this medication, consult your pharmacist.Dosage is based on your weight, medical condition, blood test results (e.g., tacrolimus trough levels), and response to treatment.Tell your doctor if your condition worsens.

Side Effects
  • See also Warning section.Shaking (tremor), headache, diarrhea, nausea/vomiting, upset stomach, loss of appetite, trouble sleeping, or tingling hands/feet may occur.
  • If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: change in the amount of urine, seizures, mental/mood changes (e.g., anxiety, agitation), extreme tiredness/weakness, swelling ankles/feet, fast/pounding heartbeat, muscle spasm, hearing problems (e.g., hearing loss, ringing in the ears), pain/redness/swelling at injection site or in the arms/legs, dizziness, easy bruising/bleeding, yellowing skin/eyes, severe stomach/abdominal pain, dark urine, shortness of breath, vision changes.Seek immediate medical attention if any of these rare but very serious side effects occur: fainting, irregular heartbeat, chest pain, black stools, vomit that looks like coffee grounds, trouble breathing.Tacrolimus may cause your blood pressure to increase.
  • You may be required to check your blood pressure periodically and/or take another medication to control your blood pressure.Tacrolimus may cause diabetes.
  • Tell your doctor or pharmacist if you experience any of the following symptoms of high blood sugar: increased thirst/hunger, frequent urination.A very serious allergic reaction to this drug is rare.
  • However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions
  • Before receiving tacrolimus, tell your doctor or pharmacist if you are allergic to it; or to other macrolide medications (e.g., sirolimus, erythromycin); or to polyoxyl 60 hydrogenated castor oil; or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, high blood pressure, diabetes, certain heart problems (e.g., QTc prolongation, slow heartbeat), mineral imbalances (e.g., high potassium, low magnesium), any recent/current infections, cancer.This medication may increase your risk of developing skin cancer.
  • Avoid prolonged sun exposure, tanning booths, and sunlamps.
  • Use a sunscreen with a high sun protection factor (SPF) and wear protective clothing when outdoors.Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose.Since this medication can increase your risk of developing serious infections, wash your hands well to prevent the spread of infections.
  • Avoid contact with people who have illnesses that may spread to others (e.g., flu, chickenpox).This drug may increase your potassium levels.
  • Before using potassium supplements or salt substitutes containing potassium, consult your doctor or pharmacist.During pregnancy, this medication should be used only when clearly needed.
  • Discuss the risks and benefits with your doctor.This drug may pass into breast milk and could have undesirable effects on a nursing infant.
  • Therefore, breast-feeding is not recommended while using this drug.
  • Consult your doctor before breast-feeding.

Missed Dose
  • For the best possible benefit, it is important to receive each scheduled dose of this medication as directed.
  • If you miss a dose, contact your doctor to establish a new dosing schedule.
  • Do not double the dose to catch up.

Drug Interactions
  • Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them.
  • Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.This drug should not be used with the following medications because very serious interactions may occur: ziprasidone, cyclosporine.If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting tacrolimus.Other drugs besides tacrolimus and ziprasidone that may affect the heart rhythm (QTc prolongation in the EKG) include amiodarone, dofetilide, pimozide, quinidine, sotalol, procainamide, and clarithromycin, among others.
  • QTc prolongation can infrequently result in serious (rarely fatal) irregular heartbeat.
  • Consult your doctor or pharmacist for more details and for instructions on how you may reduce the risk of this effect.Before receiving this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: drugs affecting liver enzymes that remove tacrolimus from your body (such as cimetidine, danazol, bromocriptine, nefazodone, ethinyl estradiol, methylprednisolone, caspofungin, St.
  • John's wort, azole antifungals including itraconazole, calcium channel blockers including nifedipine, macrolide antibiotics including erythromycin, proton pump inhibitors including omeprazole/lansoprazole, protease inhibitors including nelfinavir/ritonavir, rifamycins including rifampin/rifabutin, certain anti-seizure medicines including carbamazepine/phenytoin/phenobarbital), drugs that increase your potassium levels (e.g., potassium-sparing diuretics such as spironolactone, potassium supplements, ACE inhibitors such as lisinopril), drugs that may harm the kidneys (e.g., amphotericin B, cisplatin, ganciclovir, aminoglycosides such as gentamicin), sirolimus.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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