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Drug Guide    S   Sulfimycin

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This medication is used to treat middle ear infections in children. It is a combination of two antibiotics, erythromycin (a macrolide-type) and sulfisoxazole (a sulfa-type). This product works by stopping the growth of bacteria.This antibiotic combination treats only bacterial infections. It will not work for viral infections (e.g., common cold, flu). Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness.This medication should not be used in children younger than 2 months of age due to the risk of serious side effects.

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 Sulfimycin images:

OverviewPhotosHow To UseSide EffectsPrecautionsMissed DoseDrug Interactions

This medication is used to treat middle ear infections in children. It is a combination of two antibiotics, erythromycin (a macrolide-type) and sulfisoxazole (a sulfa-type). This product works by stopping the growth of bacteria.This antibiotic combination treats only bacterial infections. It will not work for viral infections (e.g., common cold, flu). Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness.This medication should not be used in children younger than 2 months of age due to the risk of serious side effects.
  • Do not share this medication with others.This medication has been prescribed for your current condition only.
  • Do not use it later for another infection unless told to do so by your doctor.
  • A different medication may be necessary in those cases.

  • Store in the refrigerator between 36-46 degrees F (2-8 degrees C).
  • Discard any unused medication after 14 days.
  • Keep all medicines away from children and pets.

How To Use
  • Shake the bottle well before each dose.
  • The dose should be measured out carefully with a medication spoon/cup.
  • This medication is taken by mouth usually 3 or 4 times a day or as directed by the doctor.
  • It may be taken with or without food.
  • However, nausea commonly occurs with the use of erythromycin, especially when it is taken on an empty stomach.
  • To reduce this side effect, this medication should be taken with food or milk.Though this is unlikely, kidney stones may form during treatment with this medication.
  • Drink plenty of fluids to prevent this effect unless the doctor advises you otherwise.The dosage is based on your child's medical condition, weight, and response to therapy.Antibiotics work best when the amount of medicine in your body is kept at a constant level.
  • Therefore, this drug should be taken at evenly spaced intervals.This medication should be taken until the full prescribed amount is finished, even if symptoms disappear after a few days.
  • Stopping the medication too early may allow bacteria to continue to grow, which may result in a relapse of the infection.Inform the doctor if your child's condition persists or worsens.

Side Effects
  • Nausea, vomiting, diarrhea, stomach pain/cramping, and loss of appetite may occur.
  • Taking this medication with food may lessen these symptoms.
  • Headache and dizziness may also occur.
  • If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: mouth sores, sun sensitivity (sunburn), joint pain/aches, new lump/growth in the neck (goiter), change in the amount of urine, mental/mood changes (e.g., confusion), numbness or tingling of the hands/feet.Tell your doctor immediately if any of these rare but very serious side effects occur: fainting, fast/irregular heartbeat, seizures, hearing problems (e.g., hearing loss).This medication may rarely cause serious (possibly fatal) allergic reactions and other side effects such as a severe peeling skin rash (e.g., Stevens-Johnson syndrome), blood disorders (e.g., agranulocytosis, aplastic anemia), liver damage, or lung injury.
  • Seek immediate medical attention if you notice any of the following symptoms: skin rash/blisters, itching, swelling, persistent sore throat/fever, paleness, persistent cough, trouble breathing, easy bleeding/bruising, yellowing eyes/skin, persistent nausea/vomiting, stomach/abdominal pain, unusual tiredness, dark urine.This medication may rarely cause a severe intestinal condition (pseudomembranous colitis) due to resistant bacteria.
  • This condition may occur while receiving therapy or weeks after treatment has stopped.
  • Do not use anti-diarrhea products or narcotic pain medications if you have the following symptoms because these products may make them worse.
  • Tell your doctor immediately if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool.Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection (oral or vaginal fungal infection).
  • Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge or other new symptoms.If you notice other effects not listed above, contact your doctor or pharmacist.

  • Before taking erythromycin with sulfisoxazole, tell your doctor or pharmacist if you are allergic to it; or to other macrolide antibiotics (e.g., azithromycin, clarithromycin) or sulfa medications; or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, certain type of muscle disease (myasthenia gravis), personal or family history of a certain heart problem (QTc prolongation), severe allergies, asthma, blood disorders, decreased bone marrow function (bone marrow suppression), diabetes, a certain genetic condition (glucose-6-phosphate dehydrogenase/G6PD deficiency).This medication may make you more sensitive to the sun.
  • Avoid prolonged sun exposure, tanning booths, and sunlamps.
  • Use a sunscreen and wear protective clothing when outdoors.Before having surgery, tell your doctor or dentist that you are taking this medication.Caution is advised when using this drug in the elderly because they may be more sensitive to its side effects, especially hearing loss and irregular heartbeat.This medication should not be used in children younger than 2 months of age due to the risk of serious side effects.Caution is advised when erythromycin is used in infants.
  • Although very unlikely, a stomach problem called IHPS (infantile hypertrophic pyloric stenosis) has sometimes occurred.
  • Contact your child's doctor immediately if your child has persistent vomiting or increased irritability with feeding.This medication should be used only when clearly needed during pregnancy.
  • This medication should not be used near the time of delivery because of possible harm to the unborn baby.
  • Discuss the risks and benefits with your doctor.This medication passes into breast milk and may have undesirable effects on a nursing infant.
  • Therefore, breast-feeding while using this medication is not recommended.
  • Consult your doctor before breast-feeding.

Missed Dose
  • If you miss a dose, take it as soon as you remember.
  • If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.
  • Do not double the dose to catch up.

Drug Interactions
  • Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for it.
  • Do not start, stop or change the dosage of any medicine before checking with them first.This drug should not be used with the following medications because very serious interactions may occur: eletriptan, ergot alkaloids (e.g., ergotamine, dihydroergotamine), methenamine, drugs which may affect the heart rhythm (QTc prolonging drugs such as cisapride, pimozide), ivabradine, ranolazine.If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting erythromycin with sulfisoxazole.Other drugs besides erythromycin and those listed above which may affect the heart rhythm (QTc prolongation in the EKG) include amiodarone, dofetilide, procainamide, quinidine, sotalol, moxifloxacin, gatifloxacin, and thioridazine, propafenone among others.
  • QTc prolongation can infrequently result in serious, rarely fatal, irregular heartbeats.
  • Consult your doctor or pharmacist for more details, and for instructions on how you may minimize the risk of this effect.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: colchicine, certain diabetes medications (sulfonylureas such as glipizide, glyburide, tolbutamide), digoxin, live bacterial vaccines, methotrexate, oral PABA, warfarin, drugs affecting liver enzymes that remove erythromycin from your body (such as azole antifungals including itraconazole and fluconazole, rifamycins including rifabutin, quinupristin-dalfopristin, calcium channel blockers including diltiazem and verapamil, certain anti-seizure medicines including carbamazepine and phenytoin and valproate).Erythromycin can slow down the removal of other drugs from your body by affecting certain liver enzymes.
  • Some examples of these affected drugs include alfentanil, bromocriptine, buspirone, certain benzodiazepines (alprazolam, midazolam, triazolam), caffeine-containing drugs, cilostazol, corticosteroids (e.g., prednisone), cyclosporine, eplerenone, certain erectile dysfunction medications (sildenafil, vardenafil), eszopiclone, felodipine, certain "statin" drugs (atorvastatin, lovastatin, simvastatin), quetiapine, tacrolimus, theophylline, tolterodine, vinblastine.This medication may decrease the effectiveness of combination-type birth control pills.
  • This can result in pregnancy.
  • You may need to use an additional form of reliable birth control while using this medication.
  • Consult your doctor or pharmacist for details.This drug can affect the results of certain lab tests.
  • Make sure laboratory personnel and your doctors know you are taking this medication.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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