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Drug Guide    S   SYMLIN SubQ

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   SYMLIN SubQ

SYMLIN SubQ



Pramlintide is used with mealtime insulin and a proper diet and exercise program to control high blood sugar in people with type 1 and type 2 diabetes. It is used when patients who are already using insulin need better blood sugar control. Effectively controlling high blood sugar helps prevent heart disease, strokes, kidney disease, blindness, and circulation problems, as well as sexual function problems (impotence).Pramlintide acts like the natural blood-sugar lowering hormone called amylin. It works by slowing the movement of food through your stomach. It also decreases your appetite and the amount of sugar your liver makes. Pramlintide does not replace insulin, but it may lower the amount of insulin you need.



 
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 SYMLIN SubQ images:

OverviewPhotosHow To UseSide EffectsPrecautionsMissed DoseDrug Interactions



SYMLIN SubQ

Uses
Pramlintide is used with mealtime insulin and a proper diet and exercise program to control high blood sugar in people with type 1 and type 2 diabetes. It is used when patients who are already using insulin need better blood sugar control. Effectively controlling high blood sugar helps prevent heart disease, strokes, kidney disease, blindness, and circulation problems, as well as sexual function problems (impotence).Pramlintide acts like the natural blood-sugar lowering hormone called amylin. It works by slowing the movement of food through your stomach. It also decreases your appetite and the amount of sugar your liver makes. Pramlintide does not replace insulin, but it may lower the amount of insulin you need.
Notes
  • Do not share this medication, the syringes, or the needles with others.You should attend a diabetes education program to understand diabetes, its complications, and all the important aspects of its treatment, including meals/diet, exercise, personal hygiene, medications, and getting regular eye, foot and medical exams.Keep all medical appointments.
  • Laboratory and/or medical tests (e.g.
  • fasting blood glucose, hemoglobin A1c) should be performed periodically to monitor for side effects and response to therapy.
  • Check your blood sugar levels regularly before and after meals and at bedtime, or as directed by your doctor or pharmacist.

Storage
  • Unopened vials of pramlintide should be stored in the refrigerator at 36-46 degrees F (2-8 degrees C) and protected from light.
  • Do not freeze.
  • If a vial has been frozen or overheated, throw it away.
  • Opened vials that you are using can be stored in the refrigerator or at room temperature for up to 28 days as long as the temperature is not greater than 77 degrees F (25 degrees C).
  • Discard the vial 28 days after it has been opened (punctured), whether or not it has been refrigerated, and even if some drug remains in the vial.
  • Keep all medicines away from children and pets.

Overdose
  • Symptoms of overdose may include severe nausea, vomiting, diarrhea, flushing and dizziness.

How To Use
  • Read the Medication Guide provided by your pharmacist before you start using pramlintide and each time you get a refill.
  • If you have questions regarding the information, consult your doctor or pharmacist.This medication is injected under the skin (subcutaneously) in the thigh or abdomen just before your major meals.
  • Do not use pramlintide if your blood sugar is too low, if you are planning to eat a small meal (less than 250 calories or 30 grams of carbohydrate), if you are skipping a meal.You should never mix pramlintide and insulin in the same syringe or at the same injection site.
  • If you are storing your medication in the refrigerator, make sure it is at room temperature before injecting.
  • Always use a new syringe and needle for each injection.Make sure you learn the technique and procedures for drawing up the correct dose and for self-injection.
  • Use the dosing table in the Medication Guide to find your correct dose.
  • As shown in the Medication Guide, when using a U-100 insulin syringe, a pramlintide dose of 15 micrograms equals to 2.5 units on the syringe, 30 micrograms equals to 5 units, 45 micrograms equals to 7.5 units, 60 micrograms equals to 10 units, and 120 micrograms equals to 20 units.
  • Consult your doctor or pharmacist if you have any questions.
  • Before injecting each dose, clean the injection site with rubbing alcohol.
  • It is important to change the location of the injection site daily to avoid problems under the skin.
  • Inject pramlintide in an area that is at least 2 inches (5.1 centimeter) away from your insulin injection site.
  • Before using, check this product visually for particles or discoloration.
  • If either is present, do not use the liquid.Your dosage is based on your medical condition, use of other medications, and response to therapy.
  • Do not change your dosage without consulting with your doctor.
  • Use this medication regularly in order to get the most benefit from it.
  • Learn how to store and discard needles and medical supplies safely.

Side Effects
  • Nausea, vomiting, tiredness, and upset stomach may occur as your body adjusts to the medication.
  • Nausea can be reduced by starting at a low dose and increasing the dose slowly.
  • Redness, swelling and itching at the injection site may occur and usually goes away in a few days.
  • If any of these effects persist or worsen, contact your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs.
  • Symptoms of a serious allergic reaction may include: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions
  • Before taking pramlintide, tell your doctor or pharmacist if you are allergic to it; or to the preservative metacresol; or if you have any other allergies.
  • This medication should not be used if you have certain medical conditions.
  • Before using this medication, consult your doctor or pharmacist if you have stomach/intestinal disorders (e.g., digestion problems such as gastroparesis).This medication should not be used if you, for any reason, are unable to tell when you have low blood sugar (e.g.
  • children).Before using pramlintide, tell your doctor or pharmacist your medical history, especially of: episodes of low blood sugar (hypoglycemia) needing treatment.You may experience blurred vision, dizziness or drowsiness due to extremely low or high blood sugar levels; use caution engaging in activities requiring alertness such as driving or using machinery.
  • Limit alcohol use, since alcohol can affect your blood sugar.While pramlintide does not cause low blood sugar by itself, it may increase the risk of hypoglycemia because it is used in combination with insulin.
  • Be sure you are aware of the signs of low blood sugar and know how to prevent and treat it .Symptoms of low blood sugar include chills, cold sweat, blurred vision, dizziness, drowsiness, shaking, rapid heart rate, weakness, headache, fainting, tingling of the hands or feet, or hunger.
  • It is a good habit to carry glucose tablets or gel to treat low blood sugar.
  • If you are in a situation where you don't have these reliable forms of glucose, eat a quick source of sugar such as table sugar, honey, or candy, or drink a glass of orange juice or non-diet soda to quickly raise your blood sugar level.Symptoms of high blood sugar (hyperglycemia) include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, or fruity breath odor.If symptoms of either high or low blood sugar occur, tell your doctor immediately.
  • Your medication dosage may need to be changed.During times of severe stress, such as fever, infection, injury or surgery, it may be more difficult to control your blood sugar.
  • Consult your doctor, as a change in your medication or how often you test your blood sugar may be required.This medication should be used only when clearly needed during pregnancy.
  • Discuss the risks and benefits with your doctor.
  • Follow all instructions carefully.Pramlintide passes into breast milk and may have undesirable effects on a nursing infant.
  • Consult your doctor before breast-feeding.

Missed Dose
  • If a dose is missed, skip the missed dose and resume your usual dosing schedule with the next scheduled dose.
  • Do not double the dose to catch up.

Drug Interactions
  • Your healthcare professionals (e.g.
  • doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it.
  • Do not start, stop or change dosage of any medicine before checking with them first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: anti-diabetic drugs (e.g., alpha glucosidase inhibitors such as acarbose, sulfonylureas such as glipizide, glyburide, and chlorpropamide), drugs for high blood pressure that may mask symptoms of low blood sugar, drugs that slow down or speed up digestion (e.g., atropine, exenatide, metoclopramide), drugs that can increase blood-sugar lowering effect (e.g., ACE Inhibitors such as lisinopril, disopyramide, fibrates such as clofibrate, fluoxetine, MAO inhibitors such as isocarboxazid, pentoxifylline, propoxyphene, salicylates such as aspirin, sulfa antibiotics such as sulfamethoxazole).The effectiveness of some medications may be decreased if taken at the same time as pramlintide.
  • The following medications should be taken at least 1 hour before or 2 hours after your injection: antibiotics, birth control pills, pain relievers (e.g.
  • acetaminophen).Beta-blocker medications (e.g., metoprolol, propranolol, glaucoma eye drops such as timolol) may prevent the fast/pounding heartbeat you would usually feel when your blood sugar level falls too low (hypoglycemia).
  • Other symptoms of low blood sugar such as dizziness, hunger, or sweating are unaffected by these drugs.If the medication needs to be taken with food, take it with a small meal or snack when pramlintide is not injected.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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