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Drug Guide    Q   Quadnite

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   Quadnite

Quadnite
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Promethazine is used to prevent and treat nausea and vomiting related to certain conditions (e.g., motion sickness, before/after surgery). It is also used to treat allergic symptoms such as rash, itching, and runny nose. It may be used for a short time to treat a runny nose due to the common cold. It may also be used to help you feel calmer before/after surgery or to help certain narcotic pain relievers (e.g., meperidine) work better.Promethazine is an antihistamine. It works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its other effects (e.g., anti-nausea, calming, pain relief) may work by affecting other natural substances (e.g., acetylcholine) and by acting directly on certain parts of the brain.

 
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OverviewPhotosHow To UseSide EffectsPrecautionsMissed DoseDrug Interactions
Quadnite

Uses
Promethazine is used to prevent and treat nausea and vomiting related to certain conditions (e.g., motion sickness, before/after surgery). It is also used to treat allergic symptoms such as rash, itching, and runny nose. It may be used for a short time to treat a runny nose due to the common cold. It may also be used to help you feel calmer before/after surgery or to help certain narcotic pain relievers (e.g., meperidine) work better.Promethazine is an antihistamine. It works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its other effects (e.g., anti-nausea, calming, pain relief) may work by affecting other natural substances (e.g., acetylcholine) and by acting directly on certain parts of the brain.
Notes
  • Do not share this medication with others.

Storage
  • Store at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture.
  • Do not store in the bathroom.
  • Keep all medicines away from children and pets.

Overdose
  • Symptoms of overdose may include severe dizziness, fainting, very slow/shallow breathing, loss of consciousness, muscle stiffness/twitching, hot dry skin, widened pupils.

How To Use
  • Take this medication by mouth with or without food, usually 4 times daily as needed or as directed by your doctor.
  • For motion sickness, promethazine should be taken 30-60 minutes before beginning travel.
  • If needed, the dose may be repeated 8 to 12 hours later as directed.
  • For continued travel, your doctor may direct you to take promethazine twice a day, in the morning and before the evening meal.
  • For allergies, this medication may be taken at bedtime to decrease daytime drowsiness.
  • When used before surgery, promethazine may be taken the night before or just before the procedure and may be continued afterwards.Dosage is based on your age, medical condition, and response to therapy.
  • Take this medication exactly as directed to get the most benefit from it.
  • Do not take more medication or take it more often than prescribed.
  • Ask your doctor or pharmacist if you have questions.Inform your doctor if your condition does not improve or if it worsens.

Side Effects
  • Drowsiness, dizziness, constipation, blurred vision, or dry mouth may occur.
  • If any of these effects persist or worsen, notify your doctor.Some people, particularly children, may experience excitability rather than drowsiness.Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: lack of coordination, severe dizziness, ringing ears, fainting, slow heartbeat, mental/mood changes (e.g., hallucinations, nervousness, irritability), involuntary movements (e.g., fixed upward stare, neck twisting, tongue movements), restlessness, shaking (tremor), decreased/painful urination, weakness, vision changes (e.g., double vision).Stop taking this medication and seek immediate medical attention if any of these rare but very serious side effects occur: slow/shallow breathing, signs of infection (e.g., fever, persistent sore throat), severe abdominal pain, persistent nausea/vomiting, easy bleeding/bruising, yellowing eyes/skin, dark urine.This drug may infrequently cause a very serious (rarely fatal) nervous system disorder (neuroleptic malignant syndrome).
  • If you notice any of the following unlikely but very serious side effects, stop taking this medication and seek immediate medical attention: severe muscle stiffness, mental/mood changes (e.g., sudden confusion, extreme drowsiness), very high fever, seizures, irregular/fast heartbeat, increased sweating.A very serious allergic reaction to this drug is unlikely, but stop taking this medication and seek immediate medical attention if it occurs.
  • Symptoms of a serious allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions
  • See also Warning section.Before taking promethazine, tell your doctor or pharmacist if you are allergic to it; or to any other phenothiazines (e.g., prochlorperazine); or if you have any other allergies.This medication should not be given to a person who is unconscious.This medication should not be used if you have certain medical conditions.
  • Before using this medicine, consult your doctor or pharmacist if you have: certain lung/breathing problems (e.g., asthma, chronic obstructive pulmonary disease-COPD, sleep apnea).Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood/immune system problems (e.g., bone marrow depression), a certain eye problem (narrow-angle glaucoma), heart disease (e.g., angina, irregular heartbeat), high blood pressure, liver disease, certain nervous system problems (e.g., neuroleptic malignant syndrome, Reye's syndrome), seizure, stomach/bowel problems (e.g., blockage, ulcer disease), sun sensitivity when using other medications, urination problems (e.g., due to enlarged prostate, blockage).This drug may make you dizzy or drowsy or cause blurred vision; use caution engaging in activities requiring alertness or clear vision such as driving or using machinery.
  • Avoid alcohol use.
  • Children should be supervised to avoid injury during bicycle riding or other possibly hazardous activities.Promethazine may make you more sensitive to the sun.
  • Avoid prolonged sun exposure, tanning booths, and sunlamps.
  • Use a sunscreen and wear protective clothing when outdoors.This medication can reduce sweating, making you more likely to get heat stroke.
  • Avoid strenuous work/exercise, drink plenty of fluids, and dress lightly while in hot weather.Caution is advised when using this drug in the elderly because they may be more sensitive to its effects, especially confusion and drowsiness.Caution is advised when using this drug in children because they may be more sensitive to its effects, especially slowed breathing (see Warning section).
  • Special caution should be taken in children who have lost a lot of fluid (dehydration), those who have a family history of sudden infant death syndrome (SIDS), and those who are hard to wake up from sleep.This medication should be used only when clearly needed during pregnancy.
  • Discuss the risks and benefits with your doctor.It is unknown whether promethazine passes into breast milk.
  • It may have undesirable effects on a nursing infant.
  • Therefore, breast-feeding while using this medication is not recommended.
  • Consult your doctor before breast-feeding.

Missed Dose
  • Not applicable.

Drug Interactions
  • Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for them.
  • Do not start, stop or change the dosage of any medicine before checking with them first.This drug should not be used with the following medications because very serious interactions may occur: epinephrine for low blood pressure, metrizamide, sibutramine.If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting promethazine.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially: anticholinergics (e.g., benztropine, belladonna alkaloids), cancer chemotherapy (e.g., methotrexate), guanethidine, guanadrel.Tell your doctor or pharmacist if you have taken MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine) within 2 weeks before, during or after taking promethazine.Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-seizure drugs (e.g., carbamazepine), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., chlorpromazine, risperidone, trazodone).Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients or other antihistamines.
  • Ask your pharmacist about the safe use of those products.Also report the use of drugs which might increase seizure risk (decrease seizure threshold) when combined with promethazine such as bupropion, isoniazid (INH), phenothiazines (e.g., thioridazine), theophylline, tramadol, or tricyclic antidepressants (e.g., amitriptyline), among others.
  • Consult your doctor or pharmacist for details.This medication may interfere with certain laboratory tests (including some pregnancy tests, blood sugar tests, skin test for allergies), possibly causing false test results.
  • Make sure laboratory personnel and all your doctors know you use this drug.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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