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Drug Guide    N   Nadolol-Bendroflumethiazide

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   Nadolol-Bendroflumethiazide

Nadolol-Bendroflumethiazide
Oral


This product is used with or without other medications to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.This product contains two medications. Nadolol is a beta blocker that works by blocking the effect of certain natural chemicals such as adrenaline (epinephrine) on the heart and blood vessels. This slows your heartbeat, lowers blood pressure, and reduces strain on the heart. Bendroflumethiazide is a "water pill" (diuretic) that works by increasing the amount of urine that you make. This causes your body to get rid of extra salt and water, which probably helps to relax the blood vessels so that blood can flow more easily. These two drugs are used together when one medication is not controlling your blood pressure.

 
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 Nadolol-Bendroflumethiazide images:

OverviewPhotosHow To UseSide EffectsPrecautionsMissed DoseDrug Interactions
Nadolol-Bendroflumethiazide

Uses
This product is used with or without other medications to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.This product contains two medications. Nadolol is a beta blocker that works by blocking the effect of certain natural chemicals such as adrenaline (epinephrine) on the heart and blood vessels. This slows your heartbeat, lowers blood pressure, and reduces strain on the heart. Bendroflumethiazide is a "water pill" (diuretic) that works by increasing the amount of urine that you make. This causes your body to get rid of extra salt and water, which probably helps to relax the blood vessels so that blood can flow more easily. These two drugs are used together when one medication is not controlling your blood pressure.
Notes
  • Do not share this medication with others.Lifestyle changes such as stress reduction programs, exercise, and dietary changes may increase the effectiveness of this medicine.
  • Talk to your doctor or pharmacist about lifestyle changes that might benefit you.Laboratory and/or medical tests (e.g., blood pressure, blood salt levels, liver and kidney function tests) may be performed regularly to monitor your progress or check for side effects.
  • Consult your doctor for more details.Have your blood pressure and heart rate checked regularly while taking this medication.
  • Learn how to monitor your own blood pressure and heart rate at home, and share the readings with your doctor.

Storage
  • Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture.
  • Do not store in the bathroom.
  • Keep all medicines away from children and pets.

Overdose
  • Symptoms of overdose may include: very slow heartbeat, severe dizziness, fainting, slow/shallow breathing, signs of low blood sugar (e.g., nervousness, shakiness, sweating, hunger).

How To Use
  • See also the Warning and Drug Interactions sections.Take this medication by mouth, usually once daily or as directed by your doctor.
  • Take it consistently with or without food.It is best to take this medication early in the day (before 4-6 PM) to avoid having to get up during the night to urinate.
  • Consult your doctor or pharmacist if you have questions about your dosing schedule.The dosage is based on your age, medical condition and response to therapy.
  • If you have severe liver or kidney problems, your dosage may need to be adjusted.Use this medication regularly in order to get the most benefit from it.
  • To help you remember, take it at the same time each day.
  • It is important to continue taking this medication even if you feel well.
  • Most people with high blood pressure do not feel sick.
  • It may take up to several weeks before the full benefit of this drug takes effect.Do not stop taking this medication without first consulting your doctor.
  • Some conditions may become worse when the drug is abruptly stopped.
  • Your dose may need to be gradually decreased.Inform your doctor if your condition worsens (e.g., your routine blood pressure readings increase).

Side Effects
  • Dizziness, drowsiness, headache, temporary blurred vision, nausea, bloating, gas, constipation, diarrhea, vomiting, weight gain, or dry mouth may also occur as your body adjusts to the medication.
  • You may also be more sensitive to sunburn (see Precautions section).Tell your doctor immediately if any of these unlikely but serious side effects occur: slow/irregular heartbeat, mental/mood changes (e.g., memory loss, depression, confusion), fainting, bluish fingers/toes/nails, decreased sexual ability, joint/muscle pain, increased urination, unusual shakiness/sweating, unusual hunger.Tell your doctor immediately if any of these rare but very serious side effects occur: easy bruising/bleeding, black stools, persistent rectal bleeding, signs of infection (e.g., persistent sore throat, fever), yellowing of the eyes/skin, persistent nausea/vomiting, severe stomach/abdominal pain, dark urine, slurred speech, painful erections.This product may reduce blood flow to your hands and feet, causing them to feel cold.
  • Smoking may worsen this effect.
  • Dress warmly and avoid tobacco use.Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.Medications similar to the nadolol in this product may cause or worsen heart failure.
  • Tell your doctor immediately if you notice any of the following unlikely but serious side effects: swelling of the ankles/feet, shortness of breath, severe tiredness, unexplained/sudden weight gain.Nadolol can also make it easier to have symptoms of asthma (e.g., feeling of tightness in the chest, trouble breathing, wheezing, cough).
  • Tell your doctor immediately if any of these symptoms occur.The bendroflumethiazide in this product may cause too much body water and salts to be lost (dehydration).
  • Tell your doctor immediately if you have any of these unlikely but serious symptoms of dehydration: very dry mouth, thirst, muscle cramps, weakness, fast heartbeat, severe dizziness, unusual decrease in the amount of urine, fainting, seizures.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs.
  • Symptoms of a serious allergic reaction may include: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions
  • See also the Warning section.Before taking this product, tell your doctor or pharmacist if you are allergic to nadolol or bendroflumethiazide; or to other beta blockers (e.g., atenolol, propranolol); or to other thiazides (e.g., hydrochlorothiazide); or to sulfa drugs; or if you have any other allergies.This medication should not be used if you have certain medical conditions.
  • Before using this medicine, consult your doctor or pharmacist if you have: certain types of heart rhythm problems (e.g., sinus bradycardia, second- or third-degree atrioventricular block), certain serious heart conditions (cardiogenic shock, severe heart failure), severe breathing problems (asthma, chronic obstructive pulmonary disease-COPD), or inability to make urine (anuria).Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart failure (treated, stable type), breathing problems (e.g., wheezing/cough with exercise), diabetes, overactive thyroid (e.g., hyperthyroidism), gout, blood circulation problems (e.g., Raynaud's disease, peripheral vascular disease), low blood flow to the brain (cerebral insufficiency), high levels of fats in the blood (cholesterol or triglycerides), low salts in the blood (e.g., low potassium/magnesium), loss of too much body water (dehydration), certain nerve/muscle problems (e.g., myasthenia gravis), liver problems, kidney problems, lupus, asthma, recent nerve surgery (e.g., sympathectomy).Before having surgery, tell your doctor or dentist that you are taking this medication.This drug may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery.
  • Limit alcoholic beverages.To reduce dizziness and lightheadedness, get up slowly when rising from a seated or lying position.
  • Drink plenty of fluids while taking this medication to help prevent dizziness.
  • Too much sweating, diarrhea or vomiting may cause you to lose large amounts of water and salts, causing lightheadedness.
  • Avoid heavy exercise.
  • Report prolonged diarrhea or vomiting to your doctor.This medication may reduce the potassium levels in your blood.
  • Ask your doctor about adding potassium to your diet.
  • A potassium supplement may be prescribed by your doctor.If you have diabetes, this product may mask the fast/pounding heartbeat you would usually feel when your blood sugar level falls too low (hypoglycemia).
  • Other symptoms of a low blood sugar level, such as dizziness/sweating, are unaffected by this drug.
  • This product may also make it harder to control your blood sugar levels.
  • Check your blood sugar levels regularly as directed by your doctor.
  • Tell your doctor immediately if you have symptoms of high blood sugar such as increased thirst/urination.
  • Your anti-diabetic medication or diet may need to be adjusted.Caution is advised when using this drug in the elderly because they may be more sensitive to its effects, especially dizziness and lightheadedness.Caution is advised when using this product in infants and children because they may be more sensitive to its side effects, especially low blood sugar.This medication may make you more sensitive to the sun.
  • Avoid prolonged sun exposure, tanning booths, and sunlamps.
  • Use a sunscreen and wear protective clothing when outdoors.This medication should be used only when clearly needed during pregnancy.
  • Infants exposed to the bendroflumethiazide in this product during pregnancy may have liver or bleeding problems.
  • Discuss the risks and benefits with your doctor.The medications in this product pass into breast milk.
  • The nadolol in this product may have undesirable effects on a nursing infant.
  • Breast-feeding while using this drug is not recommended.
  • Consult your doctor before breast-feeding.

Missed Dose
  • If you miss a dose, take it as soon as you remember.
  • If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.
  • Do not double the dose to catch up.

Drug Interactions
  • Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it.
  • Do not start, stop or change the dosage of any medicine before checking with them first.This drug should not be used with the following medication because a very serious interaction may occur: arbutamine, cisapride, dofetilide.If you are currently using any of these medications, tell your doctor or pharmacist before starting this product.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: alpha blockers (e.g., prazosin), anesthesia drugs, barbiturates (e.g., phenobarbital), drugs for diabetes (e.g., glipizide, glyburide, metformin), "blood thinners" (e.g., warfarin), calcium channel blockers (e.g., diltiazem, nifedipine, verapamil), clonidine, diazoxide, epinephrine, digoxin, fenoldopam, guanethidine, calcium supplements, lidocaine, lithium, methyldopa, MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine), narcotic pain relievers (e.g., codeine, morphine), reserpine, theophylline, tubocurarine, drugs that affect uric acid levels (e.g., probenecid, sulfinpyrazone), drugs that may cause potassium loss (e.g., amphotericin B, corticotropin, corticosteroids including prednisone), drugs whose removal from the body is affected by the level of acid in the urine (e.g., amphetamine, methenamine, quinidine).Cholestyramine and colestipol may decrease the absorption of this medication.
  • If you are taking either of these drugs, separate them from this medication by at least 4 hours.Check the labels on all your medicines (e.g., cough-and-cold products, diet aids, nonsteroidal anti-inflammatory drugs-NSAIDs for pain/fever reduction) because they may contain ingredients that could increase your blood pressure or cause a fast heartbeat (e.g., pseudoephedrine, phenylephrine, chlorpheniramine, diphenhydramine, clemastine, ibuprofen, naproxen).
  • Ask your pharmacist about the safe use of those products.This product can affect the results of certain lab tests (e.g., phentolamine test, protein-bound iodide, tyramine test, blood salt (electrolyte) levels, blood/urine glucose).
  • Make sure laboratory personnel and your doctors know you use this drug.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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