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Drug Guide    J   Janimine

  Prescription drug information   Post your opinion about this drug  

   Janimine

Janimine
Oral


This medication is used to treat depression. It is also used with other therapies for the treatment of nighttime bed-wetting (enuresis) in children. Using this medication to treat depression may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. Imipramine can help your child control nighttime bed-wetting.Imipramine belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of certain natural substances (neurotransmitters such as norepinephrine) in the brain. For bed-wetting, this medication may work by blocking the effect of a certain natural substance (acetylcholine) on the bladder.This drug may also be used for the treatment of anxiety, panic disorders, and certain types of ongoing pain.

 
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OverviewPhotosHow To UseSide EffectsPrecautionsMissed DoseDrug Interactions
Janimine

Uses
This medication is used to treat depression. It is also used with other therapies for the treatment of nighttime bed-wetting (enuresis) in children. Using this medication to treat depression may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. Imipramine can help your child control nighttime bed-wetting.Imipramine belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of certain natural substances (neurotransmitters such as norepinephrine) in the brain. For bed-wetting, this medication may work by blocking the effect of a certain natural substance (acetylcholine) on the bladder.This drug may also be used for the treatment of anxiety, panic disorders, and certain types of ongoing pain.
Notes
  • Do not share this medication with others.Laboratory and/or medical tests (e.g., blood counts, EKG, kidney function) may be performed regularly to monitor your progress or check for side effects.
  • Consult your doctor for more details.
  • Keep all medical appointments.

Storage
  • Store the US product in a tightly closed container at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture.Store the Canadian product in a tightly closed container at room temperature between 35.6-86 degrees F (2-30 degrees C) away from light and moisture.Do not store in the bathroom.
  • Keep all medicines away from children and pets.


How To Use
  • Read the Medication Guide available from your pharmacist.
  • Consult your doctor or pharmacist if you have any questions.Take this medication by mouth with or without food, usually 1-4 times daily or as directed by your doctor.
  • If you have daytime drowsiness, your doctor may direct you to take the entire dose once daily at bedtime.
  • Dosage is based on your medical condition and response to therapy.
  • In children, dosage may also be based on body weight.
  • To reduce your risk of side effects, your doctor may start you at a low dose and gradually increase your dose.When used in children for bed-wetting, imipramine should be taken one hour before bedtime.
  • If your child usually wets the bed early in the night, the drug may be given earlier in separate doses (e.g., one dose in the afternoon and one dose at bedtime).Follow your doctor's instructions carefully.
  • Do not take more or less medication or take it more frequently than prescribed.
  • Your condition will not improve any faster and your risk of side effects will increase.
  • Use this medication regularly in order to get the most benefit from it.
  • To help you remember, use it at the same time(s) each day.This medication does not work right away.
  • It may take up to 3 weeks before you experience the full benefits if you are taking this medication for depression.It is important to continue taking this medication even if you feel well.
  • Do not suddenly stop taking this medication without consulting your doctor.
  • Some conditions may become worse when the drug is abruptly stopped.
  • Your dose may need to be gradually decreased.When used for an extended period in children for bed-wetting, this medication may not work as well and may require different dosing.
  • Talk with the doctor if this medication stops working well.Inform your doctor if your condition persists or worsens.

Side Effects
  • Dry mouth, blurred vision, headache, drowsiness, dizziness, constipation, nausea, vomiting, loss of appetite, diarrhea, stomach cramps, weight gain/loss, and increased sweating may occur.
  • If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: fainting, mental/mood changes (e.g., confusion, depression, hallucinations, memory problems), enlarged/painful breasts, unusual breast milk production, irregular/painful menstrual periods, muscle stiffness/twitching, restlessness, ringing in the ears, sexual problems (e.g., decreased sexual ability, changes in desire), shakiness (tremors), numbness/tingling of the hands/feet, pain/redness/swelling of arms or legs, trouble urinating, severe vomiting.Tell your doctor immediately if any of these rare but very serious side effects occur: easy bruising/bleeding, signs of infection (e.g., fever, persistent sore throat), severe stomach/abdominal pain, dark urine, yellowing of eyes/skin.Seek immediate medical attention if any of these rare but very serious side effects occur: chest pain, slow/fast/irregular heartbeat, seizures, slurred speech, weakness on one side of the body, vision changes.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs.
  • Symptoms of a serious allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions
  • Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to other tricyclic antidepressants (e.g., amitriptyline); or if you have any other allergies.This medication should not be used if you have a certain medical condition.
  • Before using this medicine, consult your doctor or pharmacist if you have had: a recent heart attack.Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (e.g., asthma, chronic bronchitis), certain eye problems (e.g., glaucoma, increased intraocular pressure), diabetes, eating disorders (e.g., bulimia), heart problems (e.g., arrhythmias, coronary artery disease, heart failure), liver problems, kidney problems, personal or family history of other mental/mood conditions (e.g., bipolar disorder, schizophrenia), seizures, overactive thyroid (hyperthyroidism), trouble urinating (e.g., due to enlarged prostate), any condition that may increase your risk of seizures (e.g., alcohol/sedative dependency, use of electroconvulsive therapy, brain injury/disease such as stroke), certain types of tumors (e.g., pheochromocytoma, neuroblastoma).Before having surgery, tell your doctor or dentist that you are taking this medication.This drug may make you dizzy or drowsy or cause blurred vision; use caution engaging in activities requiring alertness or clear vision such as driving or using machinery.
  • Limit alcoholic beverages.To decrease dizziness and lightheadedness, get up slowly when rising from a seated or lying position.This drug may make you more sensitive to the sun.
  • Avoid prolonged sun exposure, tanning booths, and sunlamps.
  • Use a sunscreen and wear protective clothing when outdoors.If you have diabetes, this drug may make it harder to control your blood sugar levels.
  • Check your blood sugar regularly as directed by your doctor.
  • Tell your doctor immediately if you have symptoms such as increased thirst/urination, shakiness, unusual sweating, or hunger.
  • Your anti-diabetic medication or diet may need to be adjusted.Caution is advised when using this drug in the elderly because they may be more sensitive to the side effects of the drug, especially effects on the heart and mental/mood changes (e.g., confusion, agitation).Caution is advised when using this drug in children.
  • (See also the Warning section.)This medication should be used only when clearly needed during pregnancy.
  • Infants born to mothers who have taken similar medications during pregnancy may have symptoms such as trouble urinating, prolonged sleepiness, shaking, and seizures.
  • Discuss the risks and benefits with your doctor.This medication passes into breast milk and may have undesirable effects on a nursing infant.
  • Breast-feeding while using this drug is not recommended.
  • Consult your doctor before breast-feeding.

Missed Dose
  • If you miss a dose, take it as soon as you remember.
  • If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.
  • Do not double the dose to catch up.

Drug Interactions
  • Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it.
  • Do not start, stop or change the dosage of any medicine before checking with them first.This drug should not be used with the following medications because very serious, possibly fatal interactions may occur: arbutamine, disopyramide, sibutramine.Avoid taking MAO inhibitors within 2 weeks before, during, and after treatment with this medication.
  • In some cases a serious, possibly fatal drug interaction may occur.If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting imipramine.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: anticholinergics (e.g., atropine, belladonna alkaloids, scopolamine, drugs for Parkinson's disease such as benztropine), inhaled bronchodilators (e.g., albuterol, salmeterol), certain drugs for high blood pressure (e.g., clonidine, guanadrel, guanethidine, reserpine), digoxin, nasal decongestants (e.g., epinephrine, phenylephrine), levodopa, lithium, stimulants (e.g., amphetamine, epinephrine, methylphenidate), thyroid supplements, valproic acid, drugs affecting liver enzymes that remove imipramine from your body (e.g., alcohol, barbiturates such as phenobarbital, cimetidine, cisapride, haloperidol, certain drugs for heart rhythm such as flecainide/propafenone/quinidine, halofantrine, certain HIV protease inhibitors such as amprenavir/fosprenavir, phenothiazines such as thioridazine, pimozide, certain anti-seizure drugs such as carbamazepine/phenytoin, antidepressants such as citalopram/fluvoxamine/paroxetine/trazodone, St.
  • John's wort, terbinafine).If you have been taking fluoxetine, wait at least 5 weeks after your last dose before starting this medication.Other drugs besides imipramine which may affect the heart rhythm (QTc prolongation in the EKG) include amiodarone, dofetilide, erythromycin, procainamide, sotalol, and sparfloxacin, among others.
  • QTc prolongation can infrequently result in serious, rarely fatal irregular heartbeat.
  • Consult your doctor or pharmacist for more details and for instructions on how you may decrease the risk of this effect.Also report the use of drugs which might increase seizure risk (decrease seizure threshold) when combined with this medication such as bupropion, isoniazid (INH), theophylline, or tramadol, among others.
  • Consult your doctor or pharmacist for details.Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-anxiety drugs (e.g., diazepam), anti-seizure drugs (e.g., levetiracetam), drugs for motion sickness (e.g., meclizine).Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-containing ingredients or decongestants that could increase your heart rate or blood pressure.
  • Ask your pharmacist about the safe use of those products.Cigarette smoking decreases blood levels of this medication.
  • Tell your doctor if you smoke or if you have recently stopped smoking.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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