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Drug Guide    G   Ganphen

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   Ganphen

Ganphen
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Promethazine injection is used to treat nausea and vomiting related to certain conditions (e.g., after surgery, motion sickness). It is also used with other medication to treat life-threatening allergic symptoms (anaphylaxis) and reactions to blood products. The injectable form may be used to treat milder allergic reactions when you cannot take another medication by mouth. It may also be used before/after surgery, other procedures, or labor and delivery to help you feel calmer, to prevent nausea/vomiting, and to help certain narcotic pain relievers (e.g., meperidine) work better.Promethazine is an antihistamine (phenothiazine type). It works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its other effects (e.g., anti-nausea, calming, pain relief) may work by affecting other natural substances (e.g., acetylcholine) and by acting directly on certain parts of the brain.This medication should not be used in children younger than 2 years.

 
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OverviewPhotosHow To UseSide EffectsPrecautionsMissed DoseDrug Interactions
Ganphen

Uses
Promethazine injection is used to treat nausea and vomiting related to certain conditions (e.g., after surgery, motion sickness). It is also used with other medication to treat life-threatening allergic symptoms (anaphylaxis) and reactions to blood products. The injectable form may be used to treat milder allergic reactions when you cannot take another medication by mouth. It may also be used before/after surgery, other procedures, or labor and delivery to help you feel calmer, to prevent nausea/vomiting, and to help certain narcotic pain relievers (e.g., meperidine) work better.Promethazine is an antihistamine (phenothiazine type). It works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its other effects (e.g., anti-nausea, calming, pain relief) may work by affecting other natural substances (e.g., acetylcholine) and by acting directly on certain parts of the brain.This medication should not be used in children younger than 2 years.
Notes
  • Do not share this medication with others.

Storage
  • Store at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture.
  • Keep covered in carton until ready to use.
  • Do not store in the bathroom.
  • Keep all medicines away from children and pets.

Overdose
  • Symptoms of overdose may include: slow/shallow breathing, deep sleep, seizures, muscle spasms, flushing, widened pupils.

How To Use
  • It is best to inject this medication deep into a muscle.
  • It may also be injected into a large vein (not in the hand or wrist) by a health care professional.
  • Do not inject this medication under the skin or into an artery.
  • If you have any questions about the proper use of this medication, ask your doctor or pharmacist.Before using, check this product visually for particles or discoloration.
  • If either is present, do not use the liquid.
  • Clean the injection site well before injecting the medication.If giving this medication into a vein, inject into a running IV line (a line with IV fluid flowing in it).
  • Make sure the IV is working well before injecting.
  • Inject the medication into an injection port on the tubing as far from the vein as possible.
  • Diluting the medication may decrease risk of tissue injury.
  • Give slowly (no faster than 25 milligrams per minute).This medication can cause serious tissue damage.
  • Tell your doctor or nurse immediately if you experience pain, burning, or redness at the injection site.
  • If this occurs, the injection should be stopped and the injection site checked.Your dosage and how often you receive the medication will be determined by your weight, age, condition, and response to therapy.
  • Injections may be repeated if needed, usually every 4 hours.Inform your doctor if your condition does not improve or if it worsens.Learn how to store and discard needles and medical supplies safely.

Side Effects
  • Drowsiness, dizziness, constipation, blurred vision, or dry mouth may occur.
  • If any of these effects persist or worsen, notify your doctor.Some people, especially children, may experience excitability rather than drowsiness.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.This medication can cause severe tissue damage, possibly requiring surgery.
  • Tell your doctor/nurse immediately if you experience burning, pain, redness, swelling, or numbness at or near the injection site.Tell your doctor immediately if any of these unlikely but serious side effects occur: lack of coordination, severe dizziness, fainting, slow/fast heartbeat, muscle stiffness, involuntary muscle movements, muscle spasms (e.g., rolling eyes, twisting neck/back), restlessness, decreased/painful urination.Seek immediate medical attention if any of these unlikely but very serious side effects occur: slow/shallow breathing, difficulty waking up, hot/dry skin.Tell your doctor immediately if any of these rare but very serious side effects occur: signs of serious infection (e.g., persistent sore throat, fever), unusual bleeding/ bruising, severe stomach/abdominal pain, yellowing of eyes/skin, dark urine.This drug may infrequently cause a very serious (rarely fatal) nervous system disorder (neuroleptic malignant syndrome).
  • If you notice any of the following unlikely but very serious side effects, seek immediate medical attention: severe muscle stiffness, mental/mood changes (e.g., confusion, extreme drowsiness), high fever, seizures, irregular/fast heartbeat, increased sweating.A very serious allergic reaction to this drug is rare.
  • However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions
  • See also Warning section.Before using promethazine, tell your doctor or pharmacist if you are allergic to it; or to any other phenothiazines (e.g., prochlorperazine), or to sulfites (e.g., metabisulfite); or if you have any other allergies.This medication should not be given to a patient who is in a coma.This medication should not be used if you have certain medical conditions.
  • Before using this medicine, consult your doctor or pharmacist if you have: certain lung/breathing problems (e.g., asthma, chronic obstructive pulmonary disease-COPD, sleep apnea).Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood/immune system problems (e.g., bone marrow depression), a certain eye problem (narrow-angle glaucoma), heart disease (e.g., angina, irregular heartbeat), high or low blood pressure, liver disease, certain nervous system problem (neuroleptic malignant syndrome), Reye's syndrome, seizure, stomach/bowel problems (e.g., blockage, ulcer disease), sun sensitivity when using other medications, urination problems (e.g., due to enlarged prostate, blockage).This drug may make you dizzy or drowsy or cause blurred vision.
  • Use caution while driving, using machinery, or doing any other activity that requires alertness or clear vision.
  • Avoid alcohol use.
  • Children should be supervised during bicycle riding and other possibly hazardous activities to avoid injury.Promethazine may make you more sensitive to the sun.
  • Avoid prolonged sun exposure, tanning booths, and sunlamps.
  • Use a sunscreen and wear protective clothing when outdoors.This medication can reduce sweating, making you more likely to get heat stroke.
  • Avoid strenuous work/exercise, drink plenty of fluids, and dress lightly while in hot weather.Caution is advised when using this drug in the elderly because they may be more sensitive to its effects, especially confusion and drowsiness.Caution is advised when using this drug in children because they may be more sensitive to its effects, especially slowed breathing (see Warning section).
  • Special caution should be taken in children who a severe loss of body water (dehydration), those who have a family history of sudden infant death syndrome (SIDS), and those who are hard to wake up from sleep.During pregnancy, this medication should be used only when clearly needed.
  • Discuss the risks and benefits with your doctor.It is unknown whether promethazine passes into breast milk.
  • It may have undesirable effects on a nursing infant.
  • Therefore, breast-feeding while using this medication is not recommended.
  • Consult your doctor before breast-feeding.

Missed Dose
  • Not applicable.

Drug Interactions
  • Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them.
  • Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: anticholinergics (e.g., benztropine, belladonna alkaloids), cancer chemotherapy (e.g., methotrexate), guanethidine, guanadrel, sibutramine, MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine).Tell your doctor or pharmacist if you have taken MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) within 2 weeks before, during, or after using promethazine.Also report the use of drugs which might increase seizure risk when combined with promethazine such as bupropion, isoniazid (INH), metrizamide, phenothiazines (e.g., thioridazine), theophylline, tramadol, or tricyclic antidepressants (e.g., amitriptyline), among others.
  • Consult your doctor or pharmacist for details.Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-seizure drugs (e.g., carbamazepine), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., chlorpromazine, risperidone, trazodone).Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain ingredients that cause drowsiness.
  • Ask your pharmacist about using those products safely.This medication may interfere with certain laboratory tests (including some pregnancy tests, blood sugar tests), possibly causing false test results.
  • Make sure laboratory personnel and all your doctors know you use this drug.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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