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Drug Guide    D   Daclizumab

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   Daclizumab

Daclizumab
IV


Daclizumab is used to prevent rejection of a kidney transplant. It works by weakening your body's defense system (immune system) to help your body accept the new kidney as if it were your own. This medication is a monoclonal antibody and belongs to a class of drugs known as immunosuppressants. It is used in combination with other immunosuppressant drugs (e.g., cyclosporine, corticosteroids such as prednisone).

 
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OverviewPhotosHow To UseSide EffectsPrecautionsMissed DoseDrug Interactions
Daclizumab

Uses
Daclizumab is used to prevent rejection of a kidney transplant. It works by weakening your body's defense system (immune system) to help your body accept the new kidney as if it were your own. This medication is a monoclonal antibody and belongs to a class of drugs known as immunosuppressants. It is used in combination with other immunosuppressant drugs (e.g., cyclosporine, corticosteroids such as prednisone).
Notes
  • Laboratory and/or medical tests (e.g., complete blood counts, kidney function tests) should be performed periodically to monitor your progress or check for side effects.
  • Consult your doctor for more details.It is recommended that you attend a transplant education class or support group.
  • Learn the signs of organ rejection such as tenderness around the transplanted organ, a feeling of being ill, or fever.
  • Signs of a failing kidney transplant include a decrease in the amount of urine, swelling arms/legs/face, trouble breathing, or increase in blood pressure.
  • Seek immediate medical attention if any of these symptoms occur.

Storage
  • Store vials in the refrigerator between 36-46 degrees F (2-8 degrees C) away from light.
  • Do not shake or freeze.
  • Once the medication is mixed in IV solution, it is stable for 24 hours in the refrigerator or for 4 hours at room temperature.
  • Discard any unused portion of the vial immediately after use.


How To Use
  • This medication is given by injection into a vein by a health care professional.
  • Follow all instructions for proper mixing with IV saline solution.
  • Do not shake the vial or the solution.
  • Before using, check the medication visually for particles or discoloration.
  • If either is present, do not use the solution.
  • This medication is given over 15 minutes, usually every 14 days for a total of 5 doses, with the first dose given within 24 hours before transplantation, or as directed by your doctor.
  • If you have any questions about the use of this medication, consult your doctor or pharmacist.Dosage is based on your medical condition, weight, and response to treatment.

Side Effects
  • Nausea, vomiting, constipation, or diarrhea may commonly occur during treatment with daclizumab.
  • However, these side effects are probably caused by other drugs you are taking at the same time (e.g., cyclosporine, corticosteroids).
  • If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.This medication can lower your body's ability to fight an infection.
  • Use of drugs that weaken the immune system may also infrequently increase your risk of developing certain types of cancer (e.g., lymphoma) years after treatment.
  • Your doctor should monitor you closely for signs of these problems.
  • Tell your doctor immediately if you develop any of the following signs: signs of infection (e.g., fever, persistent sore throat, cough, painful urination), poor wound healing, unusual growths/lumps, swollen glands (e.g., on the neck, in the armpits), unexplained weight loss, night sweats, easy bruising/bleeding, abdominal pain/swelling, unusual tiredness.A very serious allergic reaction to this drug is rare.
  • However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching, swelling, severe dizziness, trouble breathing, chest pain, slow/fast/irregular heartbeat, increased sweating, redness/pain/swelling at the injection site.In a heart transplant study, use of daclizumab in combination with cyclosporine, mycophenolate mofetil, and corticosteroids may have infrequently caused an increased risk of serious (sometimes fatal) reactions.
  • Consult your doctor or pharmacist for more details.If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions
  • Before using daclizumab, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: serious infection, cancer.Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received polio vaccine by mouth or flu vaccine inhaled through the nose.Since this medication can increase your risk of developing serious infections, wash your hands well to prevent the spread of infections.
  • Avoid contact with people who have illnesses that may spread to others (e.g., flu, chickenpox).Caution is advised when using this drug in children because they may be more sensitive to its side effects, especially diarrhea, vomiting, infection, and worsening high blood pressure.Caution is advised when using this drug in the elderly because they may be more sensitive to its side effects, especially infection.During pregnancy, this medication should be used only when clearly needed.
  • Discuss the risks and benefits with your doctor.
  • It is recommended that women of childbearing age should use effective birth control before, during, and for 4 months after completion of treatment with this medication.
  • Talk to your doctor about reliable forms of birth control.It is not known whether this drug passes into breast milk.
  • Because of the possible risk to the infant, breast-feeding while using this drug is not recommended.
  • Consult your doctor before breast-feeding.

Missed Dose
  • It is important that you receive each dose of this medication as scheduled.
  • If you miss a dose, contact your doctor to establish a new dosing schedule.

Drug Interactions
  • See also Side Effects section.Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them.
  • Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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