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Drug Guide    C   Cortenema Rect

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   Cortenema Rect

Cortenema Rect

This medication is used with other treatments for certain problems with the intestines (ulcerative colitis). Using this medication as an enema allows it to work directly on the affected area as well as throughout the body. It does not cure this problem, but it may relieve pain and decrease the amount of diarrhea and bloody stools caused by swelling (inflammation). Hydrocortisone is an anti-inflammatory drug (corticosteroid hormone). It works by decreasing the body's natural defense response and decreasing inflammation.

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OverviewPhotosHow To UseSide EffectsPrecautionsMissed DoseDrug Interactions
Cortenema Rect

This medication is used with other treatments for certain problems with the intestines (ulcerative colitis). Using this medication as an enema allows it to work directly on the affected area as well as throughout the body. It does not cure this problem, but it may relieve pain and decrease the amount of diarrhea and bloody stools caused by swelling (inflammation). Hydrocortisone is an anti-inflammatory drug (corticosteroid hormone). It works by decreasing the body's natural defense response and decreasing inflammation.
  • Do not share this medication with others.Laboratory and/or medical tests (e.g., sigmoidoscopy, X-rays) should be performed regularly to monitor your progress.
  • Consult your doctor for more details.If you take this medication for a long time, wear or carry identification stating that you are using it.

  • Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture.
  • Do not store in the bathroom.
  • Keep all medicines away from children and pets.

How To Use
  • Use this drug in the rectum, usually once daily in the evening or as directed by your doctor.
  • The dosage and duration of therapy are based on your medical condition and response to therapy.For best results, use after a bowel movement.
  • Unwrap the bottle and shake well.
  • Lie on your left side with the left knee bent toward the chest.
  • Gently insert the nozzle into the rectum.
  • Gently but firmly squeeze the bottle so that all of the drug flows into the rectum.
  • Continue lying on your left side for at least 30 minutes.
  • Keep the medicine in your rectum for at least one hour and overnight if possible.Use this medication regularly in order to get the most benefit from it.
  • It may take 3-5 days to notice improvement of your symptoms.Do not use more of this product, use it more often, or keep using it for longer than prescribed by your doctor.
  • If you have been using this medication for a long time, do not suddenly stop it without your doctor's approval.
  • Some conditions may become worse when this drug is suddenly stopped.
  • Your dose may need to be gradually decreased to reduce symptoms such as extreme tiredness, weakness, weight loss, or nausea.Inform your doctor if your condition persists or worsens after 2 weeks of treatment.

Side Effects
  • Pain/discomfort in the rectal area, headache, dizziness, menstrual period changes (e.g., delayed/irregular/absent periods), trouble sleeping, increased sweating, acne, increased appetite, or unusual weight gain may occur.
  • If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: persistent rectal bleeding, dizziness, fainting, tingling/numbness in the arms/legs, easy bruising/bleeding, black stools, vomit that looks like coffee grounds, severe stomach/abdominal pain, bone/joint pain, fast/pounding/irregular heartbeat, slight to moderate weight gain, swelling of the ankles/feet, puffy face, unusual hair growth, difficult breathing, mental/mood changes (e.g., depression, mood swings, agitation), muscle weakness/pain, thinning skin, slow wound healing, increased thirst/urination, signs of infection (e.g., fever, persistent sore throat, frequent/painful urination, eye pain/discharge), vision changes, seizures, back pain, unusual skin growths.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs.
  • Symptoms of a serious allergic reaction may include: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.

  • Before using hydrocortisone enema, tell your doctor or pharmacist if you are allergic to hydrocortisone; or to other corticosteroids (e.g., prednisone); or if you have any other allergies.This medication should not be used if you have certain medical conditions.
  • Before using this medicine, consult your doctor or pharmacist if you have: certain problems in the intestines (blockage, infections including abscesses or peritonitis), recent intestinal surgeries, untreated active fungal infections.Before using this medication, tell your doctor or pharmacist your medical history, especially of: certain eye diseases (cataracts, glaucoma, herpes of the eye), certain heart problems (e.g., congestive heart failure), high blood pressure, severe liver disease (cirrhosis), kidney disease, underactive thyroid gland (hypothyroidism), diabetes, stomach/intestinal problems (e.g., diverticulitis, ulcer), brittle bones (osteoporosis), certain muscle/nerve problems (e.g., myasthenia gravis), current infections (e.g., tuberculosis, positive tuberculosis test, other herpes), bleeding problems, history of blood clots, certain mental/mood conditions (e.g., psychosis, anxiety, depression), low salts in the blood (e.g., low potassium/calcium).This drug may make you dizzy; use caution while engaging in activities requiring alertness such as driving or using machinery.
  • Limit alcoholic beverages.Before having surgery, tell your doctor or dentist that you are using this medication or have taken it within the last 12 months.Do not have immunizations, vaccinations or skin tests unless specifically directed by your doctor.
  • Avoid contact with people who have recently received oral polio vaccine.Avoid exposure to chickenpox or measles infection while taking this medication.
  • If you are exposed to these infections, seek immediate medical attention.If you have diabetes, this drug may make it harder to control your blood sugar.
  • Check your blood sugar levels regularly as directed by your doctor.
  • Tell your doctor immediately if you have symptoms of high blood sugar such as increased thirst/urination.
  • Your anti-diabetic medication or diet may need to be adjusted.If you have a history of ulcers or take large doses of aspirin or other arthritis medication, limit alcoholic beverages while taking this medication to decrease the risk of stomach/intestinal bleeding.Caution is advised when using this drug for a long time in children.
  • This medication may temporarily slow down a child's growth rate.
  • Monitor your child's height and growth rate regularly.
  • Consult your doctor for more details.This medication should be used only when clearly needed during pregnancy.
  • There have been rare reports of harm to the unborn baby.
  • Discuss the risks and benefits of taking this medication with your doctor.
  • Infants born to mothers who have been using this medication for an extended period of time may have hormone problems.
  • Tell your doctor immediately if you notice symptoms such as persistent nausea/vomiting, severe diarrhea, or weakness in your newborn.This medication passes into breast milk.
  • Consult your doctor before breast-feeding.

Missed Dose
  • If you miss a dose, use it as soon as you remember.
  • If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.
  • Do not double the dose to catch up.

Drug Interactions
  • Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it.
  • Do not start, stop or change the dosage of any medicine before checking with them first.This drug should not be used with the following medications because very serious interactions may occur: live virus vaccines, mifepristone, natalizumab.If you are currently using any of these medications, tell your doctor or pharmacist before starting hydrocortisone.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: aldesleukin, large doses of aspirin and aspirin-like drugs (salicylates), nonsteroidal anti-inflammatory drugs (NSAIDs such as indomethacin, ibuprofen), birth control pills, estrogen hormone replacement, blood thinners (e.g., warfarin), bupropion, drugs for diabetes, herbal products (e.g., licorice), isoniazid, drugs for myasthenia gravis (e.g., neostigmine, pyridostigmine), drugs affecting liver enzymes that remove hydrocortisone from your body (such as ephedrine, erythromycin, azole antifungals including ketoconazole, barbiturates including phenobarbital, rifamycins including rifampin, certain anti-seizure medications including phenytoin), drugs that may cause potassium loss (e.g., amphotericin B, water pills such as hydrochlorothiazide or furosemide), quinolone antibiotics (e.g., ciprofloxacin, levofloxacin).Check all prescription and nonprescription medicine labels carefully since many contain pain relievers/fever reducers (NSAIDs such as aspirin, ibuprofen, naproxen) which may increase the risk of stomach bleeding.
  • Low-dose aspirin, as prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention (usually at dosages of 81-325 mg per day), should be continued.
  • Consult your doctor or pharmacist for more details.This product may interfere with certain lab tests.
  • Make sure laboratory personnel and all your doctors know you use this drug.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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