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Drug Guide    C   Cafetrate Rect

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   Cafetrate Rect

Cafetrate Rect



This combination medication is used to treat or prevent a certain type of headache (vascular headaches such as migraine headaches and cluster headaches). Ergotamine helps narrow widened blood vessels in the head, which reduces the throbbing effects of vascular headaches. Caffeine increases the effects of ergotamine by also narrowing the widened blood vessels in the head.The suppository form is used when medications cannot be taken by mouth (e.g., due to nausea and vomiting).

 
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 Cafetrate Rect images:

OverviewPhotosHow To UseSide EffectsPrecautionsMissed DoseDrug Interactions
Cafetrate Rect

Uses
This combination medication is used to treat or prevent a certain type of headache (vascular headaches such as migraine headaches and cluster headaches). Ergotamine helps narrow widened blood vessels in the head, which reduces the throbbing effects of vascular headaches. Caffeine increases the effects of ergotamine by also narrowing the widened blood vessels in the head.The suppository form is used when medications cannot be taken by mouth (e.g., due to nausea and vomiting).
Notes
  • Do not share this medication with others.Certain foods/beverages or food additives (e.g., red wine, cheese, chocolate, monosodium glutamate, alcohol) as well as some lifestyle patterns (e.g., irregular eating/sleeping habits, stress) may bring about a migraine headache.
  • Avoiding these "triggers" may help decrease the frequency of migraine headaches.
  • Consult your doctor for more details.

Storage
  • Store US product in the refrigerator between 36-46 degrees F (2-8 degrees C) away from heat and moisture.
  • Do not freeze.
  • Do not store in the bathroom.Store the Canadian product below 77 degrees F (25 degrees C) away from heat and moisture.
  • Do not freeze.
  • Do not store in the bathroom.Keep all medicines away from children and pets.

Overdose
  • Symptoms of overdose may include: severe dizziness/drowsiness, loss of feeling in the fingers/toes, rapid/weak heartbeat, bluish hands/feet, seizures.

How To Use
  • Unwrap and insert one suppository rectally as directed by your doctor.
  • Remain lying down for a few minutes, and avoid having a bowel movement for an hour or longer so the drug will be absorbed.
  • The suppository is for rectal use only.If the suppository is exposed to heat and softens, chill in ice-cold water before unwrapping and using the suppository.Dosage is based on your medical condition and response to therapy.
  • This medication works best if it is used as the first signs of the headache occur.
  • If you wait until the headache has worsened, the medication may not work as well.This medication usually should be used only as needed.
  • It is not meant for long-term daily use.
  • The maximum dose is 2 suppositories for a single headache attack and 5 suppositories in any 7-day period.This medication may cause dependence, especially if it has been used regularly for an extended time (more than a few weeks) or if it has been used in high doses.
  • In such cases, if you suddenly stop this drug, "rebound headaches" may occur.
  • This headache may be different from your original headache and may last a few days.
  • Report any such headaches to your doctor immediately.
  • Consult your doctor or pharmacist for more details.Avoid eating grapefruit or drinking grapefruit juice while being treated with this medication unless your doctor instructs you otherwise.
  • Grapefruit can increase the amount of certain medications in your bloodstream.
  • Consult your doctor or pharmacist for more details.Inform your doctor if you notice increased use of this medication, the medication not working as well, a worsening of headaches, an increase in the number of headaches, or use of this medication for more than 2 headache episodes a week.
  • Your doctor may need to change your medication and/or add a separate medication to prevent the headaches.

Side Effects
  • Nausea, vomiting, restlessness, trouble sleeping, and dizziness may occur.
  • If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: rectal pain/bleeding, slow/fast/irregular heartbeat, tingling/pain/coldness in the fingers/toes, whitish fingers/toes/nails, loss of feeling in the fingers/toes, bluish hands/feet, muscle pain/weakness, severe stomach/abdominal pain, lower back pain, little or no urine.Seek immediate medical attention if any of these rare but very serious side effects occur: chest pain, vision changes, confusion, slurred speech.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs.
  • Symptoms of a serious allergic reaction may include: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions
  • Before taking this medication, tell your doctor or pharmacist if you are allergic to ergotamine or caffeine; or to other ergot alkaloids (e.g., dihydroergotamine) or to other xanthine drugs (e.g., theophylline); or if you have any other allergies.This medication should not be used if you have certain medical conditions.
  • Before using this medicine, consult your doctor or pharmacist if you have: blood circulation disease (e.g., peripheral vascular disease such as arteriosclerosis, thrombophlebitis, Raynaud's disease), uncontrolled high blood pressure, nutrient deficiency (malnutrition), heart/blood vessel disease (e.g., coronary artery disease, stroke, heart attack), liver disease, kidney disease, severe infection, severe itching.Before using this medication, tell your doctor or pharmacist your medical history, especially of: abnormal heart rhythm, smoking, diarrhea, diabetes, high blood pressure (controlled), stomach problems (e.g., ulcers).This drug may make you dizzy; use caution while engaging in activities requiring alertness such as driving or using machinery.
  • Limit alcoholic beverages.
  • Remember that alcohol may be a cause of headaches.This medication may harm an unborn baby.
  • Therefore, it must not be used during pregnancy.
  • It is recommended that men and women use two effective forms of birth control (e.g., condoms, birth control pill) while taking this medication.
  • If you become pregnant or think you may be pregnant, inform your doctor immediately.
  • Consult your doctor for more details and to discuss reliable forms of birth control.This drug may pass into breast milk and could have undesirable effects on a nursing infant.
  • Therefore, breast-feeding is not recommended while using this drug.
  • Consult your doctor before breast-feeding.

Missed Dose
  • If you miss a dose, use it as soon as you remember.
  • If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.
  • Do not double the dose to catch up.

Drug Interactions
  • (See also Warning section and How to Use section.)Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them.
  • Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.This drug should not be used with the following medications because very serious interactions may occur: delavirdine, efavirenz, sibutramine.If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting this medication.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially: adenosine, certain beta blockers (e.g., propranolol), cimetidine, dopamine, drugs affecting liver enzymes that remove ergotamine from your body (such as fluoxetine, fluvoxamine, metronidazole, nefazodone, zileuton), lithium, nicotine (e.g., nicotine gum, nicotine patches), nitrates (e.g., isosorbide, nitroglycerin), other ergot alkaloids (e.g., methysergide), theophylline.If you also take "triptan" migraine drugs (e.g., sumatriptan, rizatriptan), you will need to separate your "triptan" dose from your dose of this medication to reduce the risk of serious side effects.
  • Ask your doctor how long you should wait between your doses of these drugs.Check the labels on all your medicines (e.g., cough-and-cold products, diet aids, other migraine medications) because they may contain caffeine or other ingredients that could increase your heart rate or blood pressure.
  • Also keep in mind that certain beverages (e.g., coffee, colas, tea) contain caffeine.
  • Ask your pharmacist about the safe use of those products.This medication may interfere with certain medical/laboratory tests (including dipyridamole-thallium imaging tests, urine catecholamine levels, urine 5-HIAA levels), possibly causing false test results.
  • Make sure laboratory personnel and all your doctors know you use this drug.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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