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Drug Guide    B   Belladonna Alkaloids-Opium Rect

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   Belladonna Alkaloids-Opium Rect

Belladonna Alkaloids-Opium Rect

This medication is used to treat moderate-to-severe pain from spasm of the tubes that drain urine from the kidneys to the bladder (ureters). Belladonna/opium suppositories are used when regular pain medicines are not working well or when it would be better to take narcotic pain medicines less often. This product contains 2 medicines; opium (a narcotic pain medicine) and belladonna (an anticholinergic). The opium helps to relieve pain, and belladonna helps to relieve spasms.

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OverviewPhotosHow To UseSide EffectsPrecautionsMissed DoseDrug Interactions
Belladonna Alkaloids-Opium Rect

This medication is used to treat moderate-to-severe pain from spasm of the tubes that drain urine from the kidneys to the bladder (ureters). Belladonna/opium suppositories are used when regular pain medicines are not working well or when it would be better to take narcotic pain medicines less often. This product contains 2 medicines; opium (a narcotic pain medicine) and belladonna (an anticholinergic). The opium helps to relieve pain, and belladonna helps to relieve spasms.
  • Do not share this medication with others.
  • It is against the law.Keep all medical appointments so that your doctor can monitor your progress or check for side effects.
  • Consult your doctor for more details.This medication has been prescribed for your current condition only.
  • Do not use it later for another condition unless told to do so by your doctor.
  • A different medication may be necessary in that case.

  • Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture.
  • Do not refrigerate.
  • Do not store in the bathroom.
  • Keep all medicines away from children and pets.

  • Symptoms of overdose may include: restlessness, unusual behavior, excitability, fainting, slowed breathing, inability to move (paralysis), inability to wake up (coma).

How To Use
  • Insert 1 suppository into the rectum, usually 1-2 times daily or as directed by your doctor.
  • Do not use more than 4 doses in a 24-hour period.
  • Follow the package instructions on how to insert a suppository.
  • Before using this product, wash your hands, then unwrap the suppository and moisten it with water.
  • Lie on your back with your knees toward your chest.
  • Gently insert 1 suppository into the rectum by slowly pushing it in with your finger about 1 inch (2.5 centimeters).
  • Remain lying down for a few minutes, and avoid having a bowel movement for an hour or longer so the drug will be absorbed.
  • Wash your hands after use.Dosage is based on your medical condition and response to therapy.Use this medication regularly to get the most benefit from it.
  • To help you remember, use it at the same time(s) each day.This medication may cause dependence, especially if it has been used regularly for an extended time or if it has been used in high doses.
  • In such cases, withdrawal reactions (e.g., shakiness, sweating, nausea) may occur if you suddenly stop this drug.
  • To prevent withdrawal reactions when stopping extended, regular treatment with this drug, gradually reduce the dosage as directed.
  • Consult your doctor or pharmacist for more details, and report any withdrawal reactions immediately.Though very unlikely, abnormal drug-seeking behavior (addiction) is possible with this medication.
  • To lessen the risk of becoming addicted, do not increase your dose, use it more frequently, or use it for a longer time than prescribed.
  • Properly stop the medication when so directed.When used for an extended period, this medication may not work as well and may require different dosing.
  • Talk with your doctor if this medication stops working well.Immediately inform your doctor if your pain persists or worsens.

Side Effects
  • Drowsiness, blurred vision, vision that is sensitive to light, dry mouth, dry eyes, nausea, vomiting, constipation, or fast heartbeat may occur.
  • If any of these effects persist or worsen, tell your doctor or pharmacist promptly.To relieve dry mouth, suck on hard candy or ice chips, chew gum, drink water, or use a saliva substitute.To prevent constipation, maintain a diet adequate in fiber, and drink plenty of water.
  • If you become constipated while using this drug, consult your pharmacist for help in selecting a laxative (e.g., stimulant-type with stool softener).Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: fast/irregular heartbeat, weakness, headache, mental/mood changes (e.g., nervousness, confusion), loss of taste, severe constipation, urination problems (e.g., difficulty starting urination, slowed urination), decreased sexual ability/interest.A very serious allergic reaction to this drug is rare.
  • However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.

  • Before using belladonna/opium suppositories, tell your doctor or pharmacist if you are allergic to belladonna or opium; or to other narcotics (e.g., morphine); or to atropine; or if you have any other allergies.This medication should not be used if you have certain medical conditions.
  • Before using this medicine, consult your doctor or pharmacist if you have: glaucoma, urine blockage due to enlarged prostate, blockage or narrowing in the stomach/intestines, severe slowing or stoppage of the intestines (e.g., intestinal atony, paralytic ileus), a certain type of infectious diarrhea (pseudomembranous colitis), any condition that causes immobility (being bedridden), severe bleeding, a certain severe form of an intestinal disease (ulcerative colitis), a certain muscle disease (myasthenia gravis), severe liver disease, severe kidney disease, severe breathing problems (e.g., respiratory depression, asthma attack), intoxication with drugs that depress the nervous system or your breathing (such as alcohol or tranquilizers/sedatives), heart rhythm problems, heart failure due to long-term lung disease, brain disorders (e.g., head injury/tumor, increased intracranial pressure), uncontrolled seizures.Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems, kidney problems, ulcerative colitis, other heart disease (e.g., angina, previous heart attack), high blood pressure, nerve problems causing slowing of the intestines (autonomic neuropathy), hiatal hernia with heartburn, lung diseases (e.g., chronic obstructive pulmonary disease-COPD, low oxygen in the blood, high carbon dioxide in the blood), low blood pressure, alcohol withdrawal, disease of the pancreas (e.g., pancreatitis), mental/mood disorders (e.g., toxic psychosis, depression), a certain spinal problem (kyphoscoliosis), gallbladder disease, personal or family history of regular use/abuse of drugs/alcohol, adrenal gland problem (e.g., Addison's disease), uncontrolled underactive or overactive thyroid, sleep apnea.This drug may make you dizzy or drowsy.
  • Use caution while driving, using machinery, or taking part in any other activity that requires alertness.
  • Avoid alcoholic beverages because they may increase the risk of side effects.To lower your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.Caution is advised when using this drug in the elderly because they may be more sensitive its effects, especially urination problems, drowsiness, confusion, slow/shallow breathing, and low blood pressure.During pregnancy, this medication should be used only when clearly needed.
  • Using it for long periods or in high doses near the expected delivery date is not recommended because of possible harm to the unborn baby.
  • Discuss the risks and benefits with your doctor.
  • Infants born to mothers who have used this medication for an extended time may have withdrawal symptoms such as irritability, abnormal/persistent crying, vomiting, or diarrhea.
  • Tell your doctor immediately if you notice any of these symptoms in your newborn.This medication passes into breast milk and may have undesirable effects on a nursing infant.
  • Consult your doctor before breast-feeding.
  • This medication may also decrease the amount of breast milk that you make.

Missed Dose
  • If you miss a dose, use it as soon as you remember.
  • If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.
  • Do not double the dose to catch up.

Drug Interactions
  • Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them.
  • Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.This drug should not be used with the following medications because very serious interactions may occur: naltrexone, MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine, rasagiline), pramlintide, oral solid potassium supplements.If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting belladonna/opium suppositories.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: other narcotic pain relievers (e.g., codeine), beta blockers (e.g., propranolol), warfarin, rifampin, cimetidine, certain mental/mood medications (e.g., clozapine, chlorpromazine), certain antidepressants (e.g., amitriptyline, nortriptyline, trazodone), certain antihistamines (e.g., diphenhydramine, chlorpheniramine).Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain ingredients that have similar side effects as the belladonna in this product (e.g., drowsiness, dry eyes, dry mouth, constipation, urination problems).
  • Ask your pharmacist about using those products safely.Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as anti-seizure drugs (e.g., carbamazepine), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants (e.g., methocarbamol).

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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