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Drug Guide    A   Azacitidine SubQ

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   Azacitidine SubQ

Azacitidine SubQ



This medication is used to treat a group of blood/bone marrow disorders (myelodysplastic syndromes-MDS) in which the bone marrow does not produce enough healthy blood cells. People with MDS usually have problems such as infections, anemia, and easy bleeding/bruising. Azacitidine is a chemotherapy drug. It is believed to work by helping your bone marrow grow normal blood cells so you will need fewer blood transfusions. Azacitidine also kills abnormal blood cells that have grown too fast and do not work properly.

 
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 Azacitidine SubQ images:

OverviewPhotosHow To UseSide EffectsPrecautionsMissed DoseDrug Interactions
Azacitidine SubQ

Uses
This medication is used to treat a group of blood/bone marrow disorders (myelodysplastic syndromes-MDS) in which the bone marrow does not produce enough healthy blood cells. People with MDS usually have problems such as infections, anemia, and easy bleeding/bruising. Azacitidine is a chemotherapy drug. It is believed to work by helping your bone marrow grow normal blood cells so you will need fewer blood transfusions. Azacitidine also kills abnormal blood cells that have grown too fast and do not work properly.
Notes
  • Do not share this medication with others.Laboratory and/or medical tests (e.g., complete blood counts-CBC, kidney function, liver function, blood bicarbonate levels) should be performed periodically to monitor your progress or check for side effects.
  • Consult your doctor for more details.

Storage
  • For unmixed medication: Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture.
  • Brief storage between 59-86 degrees F (15-30 degrees C) is permitted.For mixed medication: If this drug is being given under the skin, it may be stored at room temperature for up to 1 hour, or it may be stored up to 8 hours if refrigerated between 36-46 degrees F (2-8 degrees C).
  • If this medication is being given by injection into a vein, it must be used within 1 hour after mixing.Properly discard any unused liquid.


How To Use
  • This medication is given by injection under the skin or into a vein by a health care professional.
  • Health care professionals must follow all the manufacturer's instructions for properly mixing and giving this drug.
  • If you have any questions about using this medication properly, consult your doctor or pharmacist.When injecting this medication under the skin, it is important to change the location of the injection site daily to avoid problem areas under the skin.Dosage is based on your medical condition, body size, laboratory test results, and response to treatment.
  • Keep all medical/laboratory appointments.This medication is injected once a day for 7 days in a row or as directed by your doctor.
  • A 7-day course of this medication is called a cycle.
  • This cycle is repeated every 4 weeks depending on your response and blood tests.Use care when preparing or giving this medication.
  • Avoid getting this medication on the skin or in the eyes, mouth, or nose.
  • If you do get this medication in those areas, flush with plenty of water and tell your doctor immediately.

Side Effects
  • Redness/pain/bruising at the injection site, tiredness, diarrhea, dizziness, trouble sleeping, constipation, nausea, vomiting, and loss of appetite may occur.
  • Nausea and vomiting can be severe.
  • In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting.
  • Eating several small meals, not eating before treatment, or limiting activity may help lessen some of these effects.
  • If these effects persist or worsen, tell your doctor or pharmacist promptly.Many people using this medication have serious side effects.
  • However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk of side effects.
  • Careful monitoring by your doctor may decrease your risk.Tell your doctor immediately if any of these serious side effects occur: easy bleeding/bruising, chest pain, muscle/joint pain, muscle cramps, irregular heartbeat, swollen ankles/feet, mental/mood changes (e.g., anxiety, depression).Tell your doctor immediately if any of these rare but very serious side effects occur: change in the amount of urine, dark urine, yellowing eyes/skin.This medication can lower the body's ability to fight an infection.
  • Tell your doctor immediately if you develop any signs of an infection such as fever, chills, cough, or persistent sore throat.A very serious allergic reaction to this drug is rare.
  • However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions
  • Before using azacitidine, tell your doctor or pharmacist if you are allergic to it; or to mannitol; or if you have any other allergies.This medication should not be used if you have certain medical conditions.
  • Before using this medicine, consult your doctor or pharmacist if you have: liver cancer.Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease.Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose.
  • Wash your hands well to prevent the spread of infections.To lower your risk of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.This drug may make you dizzy.
  • Use caution while driving, using machinery, or doing any other activity that requires alertness.
  • Limit alcoholic beverages.This medication is not recommended for use during pregnancy.
  • Also, men using this medication should avoid causing pregnancy during treatment.
  • It is recommended that men and women use 2 effective forms of birth control (e.g., condoms and birth control pills) while using this medication and for some time afterward.
  • Consult your doctor for more details and to discuss reliable forms of birth control.It is not known whether this drug passes into breast milk.
  • Because of the possible risk to the infant, breast-feeding while using this drug is not recommended.
  • Consult your doctor before breast-feeding.

Missed Dose
  • For the best possible benefit, it is important to receive each scheduled dose of this medication as directed.
  • If you miss a dose, contact your doctor to establish a new dosing schedule.
  • Do not double the dose to catch up.

Drug Interactions
  • Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them.
  • Do not start, stop, or change the dosage of any medicine before checking with them first.This drug should not be used with the following medications because very serious interactions may occur: live vaccines (e.g., flu vaccine inhaled through the nose, typhoid/polio vaccine taken by mouth).If you have recently used or are planning to use any of these medications, tell your doctor or pharmacist before starting azacitidine.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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