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Drug Guide    A   Apresodex

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This medication is used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.This product contains two medications, hydralazine and hydrochlorothiazide. Hydralazine is called a vasodilator and works by relaxing blood vessels so blood can flow more easily. Hydrochlorothiazide is called a water pill (diuretic) that causes your body to get rid of extra salt and water. This increases the amount of urine you make. Getting rid of extra water and salt probably also helps to relax the blood vessels so that blood can flow more easily. These drugs are used together when one medication is not controlling your blood pressure.

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 Apresodex images:

OverviewPhotosHow To UseSide EffectsPrecautionsMissed DoseDrug Interactions

This medication is used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.This product contains two medications, hydralazine and hydrochlorothiazide. Hydralazine is called a vasodilator and works by relaxing blood vessels so blood can flow more easily. Hydrochlorothiazide is called a water pill (diuretic) that causes your body to get rid of extra salt and water. This increases the amount of urine you make. Getting rid of extra water and salt probably also helps to relax the blood vessels so that blood can flow more easily. These drugs are used together when one medication is not controlling your blood pressure.
  • Do not share this medication with others.Lifestyle changes such as stress reduction programs, exercise, and dietary changes may increase the effectiveness of this medicine.
  • Talk to your doctor or pharmacist about lifestyle changes that might benefit you.Laboratory and/or medical tests (e.g., blood salt levels, blood pressure, complete blood count, antinuclear antibody titer) may be performed from time to time to monitor your progress or check for side effects.
  • Consult your doctor for more details.Have your blood pressure checked regularly while taking this medication.
  • Learn how to monitor your own blood pressure, and share the readings with your doctor.

  • Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture.
  • Do not store in the bathroom.
  • Keep all medicines away from children and pets.

  • Symptoms of overdose may include: fainting, severe dizziness, severe headaches, chest pain, jaw/left arm pain, cold sweats, irregular breathing, blue lips, fast or weak heartbeat.

How To Use
  • Take this medication by mouth with or without food, usually twice daily or as directed by your doctor.
  • It is best to take the last dose of this medication early in the day (before 4-6 PM) to avoid having to get up during the night to urinate.
  • Consult your doctor or pharmacist if you have questions about your dosing schedule.The dosage is based on your age, medical condition and response to therapy.
  • If you have severe liver or kidney problems, your dosage may need to be adjusted.Use this medication regularly in order to get the most benefit from it.
  • To help you remember, take it at the same time each day.
  • It is important to continue taking this medication even if you feel well.
  • Most people with high blood pressure do not feel sick.
  • It may take up to several weeks before the full benefit of this drug takes effect.Do not stop taking this medication without first consulting your doctor.
  • Some conditions may become worse when the drug is abruptly stopped.
  • Your dose may need to be gradually decreased.Inform your doctor if your condition worsens (e.g., your routine blood pressure readings increase).

Side Effects
  • Dizziness, lightheadedness, headache, temporary blurred vision, loss of appetite, flushing, nausea, vomiting, diarrhea, or constipation may occur as your body adjusts to the medication.
  • If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
  • You may also be more sensitive to sunburn (see Precautions section).Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.The hydrochlorothiazide in this product may cause too much body water and salts to be lost (dehydration).
  • Tell your doctor immediately if you have any of these unlikely but serious symptoms of dehydration: very dry mouth, thirst, muscle cramps, weakness, fast heartbeat, nausea, vomiting, severe dizziness, confusion, unusual decrease in the amount of urine, fainting, seizures.Tell your doctor immediately if any of these unlikely but serious side effects occur: chest pain, shortness of breath, uncontrolled movements (e.g., tremor), mental/mood changes (e.g., depression, anxiety), trouble urinating, unusual tiredness, vision changes (e.g., yellow vision), severe constipation, severe stomach/abdominal pain, increased thirst, increased urination.This medication may infrequently cause nerve problems.
  • Notify your doctor promptly if you experience numbness or tingling.
  • Your doctor may recommend a vitamin B6 supplement (pyridoxine).This medication may infrequently cause a serious immune system problem (systemic lupus erythematosus), which may occur with or without severe kidney problems (glomerulonephritis).
  • Tell your doctor immediately if you experience any of these unlikely but serious side effects: unusual tiredness, joint/muscle aches, unusual fever, butterfly-shaped facial rash, swollen glands, bloody/pink urine, swelling of the feet/ankles (edema).Your doctor may need to order special tests if you experience these symptoms.
  • Keep all laboratory and medical appointments.Tell your doctor immediately if any of these rare but very serious side effects occur: signs of infection (e.g., fever, persistent sore throat), easy bruising/bleeding, yellowing of the eyes/skin, dark urine, persistent nausea/vomiting.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs.
  • Symptoms of a serious allergic reaction may include: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.

  • Before taking this product, tell your doctor or pharmacist if you are allergic to it; or to other thiazide diuretics (e.g., polythiazide, chlorthalidone); or to other sulfa drugs; or if you have any other allergies.This medication should not be used if you have certain medical conditions.
  • Before using this medicine, consult your doctor or pharmacist if you have: inability to make urine (anuria), chest pain (angina), previous heart attack, heart valve problems (rheumatic heart disease of the mitral valve).Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood vessel problems (cerebrovascular disease), high pressure in the brain (intracranial pressure), kidney problems, liver problems, asthma, diabetes, a certain immune system disease (lupus), low salts in the blood (e.g., low potassium/magnesium), loss of too much body water (dehydration), gout, recent nerve surgery (e.g., sympathectomy), high levels of fats in the blood (high cholesterol/triglycerides), parathyroid problems, blood calcium problems.This drug may make you dizzy or drowsy or cause temporary blurred vision; use caution while engaging in activities requiring alertness such as driving or using machinery.
  • Limit alcoholic beverages.To minimize dizziness and lightheadedness, get up slowly when rising from a seated or lying position.Drink plenty of fluids while taking this medication to help prevent dizziness.
  • Too much sweating, diarrhea or vomiting may cause you to lose large amounts of water and salts, causing lightheadedness.
  • Avoid heavy exercise.
  • Report prolonged diarrhea or vomiting to your doctor.This medication may make you more sensitive to the sun.
  • Avoid prolonged sun exposure, tanning booths, and sunlamps.
  • Use a sunscreen and wear protective clothing when outdoors.This medication may decrease the potassium levels in your blood.
  • Ask your doctor about getting extra potassium from food or a potassium supplement, which may be prescribed by your doctor.If you have diabetes, this product may increase your blood sugar levels.
  • Check your blood sugar levels regularly as directed by your doctor.
  • Tell your doctor immediately if you have symptoms of high blood sugar such as increased thirst and urination.
  • Your anti-diabetic medication or diet may need to be adjusted.Caution is advised when using this drug in the elderly because they may be more sensitive to its effects, especially dizziness.Before having surgery, tell your doctor or dentist that you are taking this medication.This medication should be used only when clearly needed during pregnancy.
  • Infants born to mothers who have taken hydrochlorothiazide during pregnancy may have liver or bleeding problems.
  • Discuss the risks and benefits with your doctor.It is not known if the hydralazine in this product passes into breast milk.
  • The hydrochlorothiazide in this product passes into breast milk.
  • Breast-feeding while using this drug is not recommended.
  • Consult your doctor before breast-feeding.

Missed Dose
  • If you miss a dose, take it as soon as you remember.
  • If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.
  • Do not double the dose to catch up.

Drug Interactions
  • See also the How to Use section.Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it.
  • Do not start, stop or change the dosage of any medicine before checking with them first.Avoid taking MAO inhibitors (furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine) within 2 weeks before and after treatment with this medication.
  • In some cases a serious, possibly fatal drug interaction may occur.If taken together with this drug, cholestyramine and colestipol can decrease the amount of this medication that is absorbed by your body.
  • If you are taking either of these drugs, separate them from this medication by at least 4 hours.This drug should not be used with the following medications because very serious interactions may occur: cisapride, dofetilide.If you are currently using any of these medications, tell your doctor or pharmacist before starting this product.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: anesthesia drugs, barbiturates (e.g., phenobarbital), drugs for diabetes (e.g., insulin, glipizide, glyburide), diazoxide, digoxin, epinephrine, guanethidine, lithium, certain nonsteroidal anti-inflammatory drugs-NSAIDs (e.g., celecoxib, ibuprofen, indomethacin), methyldopa, tubocurarine, drugs that may cause potassium loss (e.g., amphotericin B, corticotropin, corticosteroids including prednisone), drugs whose removal from the body is affected by acid levels in urine (e.g., amphetamine, methenamine, quinidine).Check the labels on all your medicines (e.g., cough-and-cold products, diet aids, nonsteroidal anti-inflammatory drugs-NSAIDs for pain/fever reduction) because they may contain ingredients that could increase your blood pressure or cause a fast heartbeat (e.g., pseudoephedrine, phenylephrine, chlorpheniramine, diphenhydramine, clemastine, ibuprofen, naproxen).
  • Ask your pharmacist about the safe use of those products.This product can affect the results of certain lab tests (amylase, protein-bound iodine, parathyroid, certain tests for pheochromocytoma, urine estrogen).
  • Make sure laboratory personnel and your doctors know you use this drug.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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