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Drug Guide    A   Amphotericin B

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   Amphotericin B

Amphotericin B
Inj


See also Warning section.This medication is used to treat a variety of serious, possibly fatal fungal infections. It works by stopping the growth of fungi.This drug may also be used to prevent fungal infections in patients with fevers and low white blood cell (neutrophil) counts or patients with weakened immune systems (e.g., due to HIV, organ transplant, or cancer).

 
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 Amphotericin B images:

OverviewPhotosHow To UseSide EffectsPrecautionsMissed DoseDrug Interactions
Amphotericin B

Uses
See also Warning section.This medication is used to treat a variety of serious, possibly fatal fungal infections. It works by stopping the growth of fungi.This drug may also be used to prevent fungal infections in patients with fevers and low white blood cell (neutrophil) counts or patients with weakened immune systems (e.g., due to HIV, organ transplant, or cancer).
Notes
  • This medication should be given in a hospital setting where your condition and response can be closely monitored.Laboratory and/or medical tests (e.g., kidney/liver function tests, potassium/magnesium levels, complete blood counts) should be performed periodically to monitor your progress or check for side effects.
  • Consult your doctor for more details.

Storage
  • Refrigerate unopened vials between 36-46 degrees F (2-8 degrees C) away from light.
  • Once mixed with sterile water for injection, the amphotericin in the vial may be stored at room temperature between 59-86 degrees F (15-30 degrees C) for 24 hours or refrigerated for up to 7 days, away from light.
  • Solutions prepared for infusion should be used right away and protected from light during infusion.

Overdose
  • Symptoms of overdose may include: dizziness, fainting, slow heartbeat, trouble breathing.

How To Use
  • This medication is given slowly into a vein (infusion) by a health care professional.
  • Follow all instructions for proper mixing and dilution with the correct IV fluid.
  • Before using this product, check it visually for particles or discoloration.
  • If either is present, do not use the liquid.
  • If you have questions about the use of this medication, consult the pharmacist.Your doctor may give you a smaller dose first to test your response to the medication.
  • This medication is usually given once a day or every other day over 2 to 6 hours.
  • The total daily dose of the medication must not exceed 1.5 milligram per kilogram.Dosage is based on your medical condition, weight, response to the test dose, and response to therapy.
  • If this medication is stopped for 7 days or longer, then it should be restarted at the lowest dose and slowly increased.It may be necessary to continue this medication for several weeks to several months in order to treat certain infections.
  • Stopping the medication too early may result in a return of the infection.Inform your doctor if your condition persists or worsens.

Side Effects
  • Fever, shaking, chills, flushing, loss of appetite, dizziness, nausea, vomiting, headache, shortness of breath, or fast breathing may occur 1 to 3 hours after the infusion is started.
  • In some cases, other medications (e.g., acetaminophen, diphenhydramine, corticosteroids such as hydrocortisone) may be necessary to prevent or relieve these side effects.
  • If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: swelling/pain at injection site, muscle/joint pain, unusual tiredness, weakness, muscle cramping, change in the amount of urine, painful urination, numbness/tingling of arms/legs, vision changes, hearing changes (e.g., ringing in the ears).Tell your doctor immediately if any of these rare but very serious side effects occur: dark urine, severe stomach/abdominal pain, yellowing eyes/skin, swelling ankles/feet, fast/slow/irregular heartbeat, cold sweats, blue lips, easy bruising/bleeding, other signs of infection (e.g., fever, persistent sore throat), mental/mood changes, seizures, black stools, vomit that looks like coffee grounds.A very serious allergic reaction to this drug is rare.
  • However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions
  • Before receiving amphotericin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: white blood cell (leukocyte) transfusions, heart disease (e.g., irregular heartbeat, congestive heart failure), liver disease, kidney disease.During pregnancy, this medication should be used only when clearly needed.
  • Discuss the risks and benefits with your doctor.This drug may pass into breast milk and could have undesirable effects on a nursing infant.
  • Therefore, breast-feeding is not recommended while using this drug.
  • Consult your doctor before breast-feeding.

Missed Dose
  • It is important not to miss any doses of this medication and to use each dose as scheduled.
  • If you miss a dose, contact your doctor or pharmacist immediately to establish a new dosing schedule.

Drug Interactions
  • Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them.
  • Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.This drug should not be used with the following medication because very serious interactions may occur: cidofovir.If you are currently using the medication listed above, tell your doctor or pharmacist before starting amphotericin.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: anti-cancer drugs (e.g., mechlorethamine, nitrogen mustard), azole antifungals (e.g., ketoconazole, itraconazole), digoxin, flucytosine, medications that affect the kidneys (e.g., cyclosporine, aminoglycosides such as gentamicin, pentamidine, tacrolimus), medications that lower potassium levels (e.g., corticosteroids such as hydrocortisone), muscle relaxants (e.g., tubocurarine), zidovudine.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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