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Drug Guide    A   Amphotericin B-Injection

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   Amphotericin B-Injection

Amphotericin B-Injection

Amphotericin B is used to treat a fungal infection.


Fungizone Iv, Amphocin
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OverviewPhotosHow To UseSide EffectsPrecautionsMissed DoseDrug Interactions
Amphotericin B-Injection
Fungizone Iv, Amphocin

Amphotericin B is used to treat a fungal infection.

  • Unopened vials should be refrigerated.
  • Once prepared, the reconstituted vial (of concentrated solution 5mg/ml) may be refrigerated for up to 7 days.
  • At room temperature it is stable for only 24 hours and must be protected from light.
  • Solutions diluted for infusion (0.1mg/ml or less) should be used promptly after mixing and should be protected from light during administration.
  • Check the expiration date on the label and properly discard of any unused medication after that time.

  • If overdose is suspected, contact your local poison control center or emergency room immediately.
  • Symptoms of overdose may include dizziness, unusually slow heartbeat, or seizures.

How To Use
  • Amphotericin B is administered by infusion into a vein by a health care professional.
  • It is usually given once a day or every other day.
  • It may be necessary to continue therapy with Amphotericin B for several weeks to months in certain cases.
  • Stopping therapy too soon may result in ineffective treatment.

Side Effects
  • Fever and chills may occur 1 to 2 hours after the infusion is started.
  • This is more common with the first few doses and should subside as therapy continues.
  • Nausea, vomiting, diarrhea, weakness, muscle aches, headache and irritation at the injection site may also occur.
  • To help minimize these effects, you may be given a pain reliever or other medication before each dose.
  • If these effects persist or worsen, notify your doctor promptly.
  • Notify your doctor promptly if you experience: irregular or rapid heartbeat, severe weakness, vision changes, tingling of the hands or feet, ringing in the ears, trouble urinating.
  • In the unlikely event you have an allergic reaction to Amphotericin B, seek medical attention immediately.
  • Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing.
  • If you notice other effects not listed above, contact your doctor or pharmacist.

  • Tell your doctor your medical history, especially of: heart disease, liver disease, kidney disease, any allergies.
  • Amphotericin B should be used only if clearly needed during pregnancy.
  • Use of Amphotericin B is not recommended while breast-feeding.
  • Discuss the risks and benefits with your doctor.

Missed Dose
  • It is important to use each dose as scheduled.
  • If you miss a dose, contact your health care provider who will help establish a new dose schedule.
  • Do not double-up the dose to catch up.

Drug Interactions
  • Tell your doctor of any nonprescription or prescription medication you may take particularly: steroids (e.g., prednisone), digoxin, cyclosporine, anti-cancer medications, other anti-fungal drugs, tacrolimus.
  • Do not start or stop any medicine without doctor or pharmacist approval.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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