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Additional Details
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Drug Guide    A   Aminoglutethimide

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   Aminoglutethimide

Aminoglutethimide
Oral


Aminoglutethimide is used to treat Cushing's syndrome, a disease that occurs when the body produces too much cortisol and other hormones. Cortisol is a natural substance that is needed by the body to deal with stress and keep the body working well. Too much of these hormones causes many problems such as blood pressure changes, weight changes, muscle/bone weakness, thinning skin, and diabetes. This medication is used to stop the adrenal gland from making too much cortisol and other hormones. It is often used for a short time until other treatments can be done.

 
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 Aminoglutethimide images:

OverviewPhotosHow To UseSide EffectsPrecautionsMissed DoseDrug Interactions
Aminoglutethimide

Uses
Aminoglutethimide is used to treat Cushing's syndrome, a disease that occurs when the body produces too much cortisol and other hormones. Cortisol is a natural substance that is needed by the body to deal with stress and keep the body working well. Too much of these hormones causes many problems such as blood pressure changes, weight changes, muscle/bone weakness, thinning skin, and diabetes. This medication is used to stop the adrenal gland from making too much cortisol and other hormones. It is often used for a short time until other treatments can be done.
Notes
  • Do not share this medication with others.Laboratory and/or medical tests (e.g., complete blood count, cortisol, electrolytes, liver/thyroid tests) should be performed periodically to monitor your progress or check for side effects.
  • Consult your doctor for more details.Have your blood pressure checked regularly while taking this medication.
  • You may want to learn how to monitor your own blood pressure at home, and share the results with your doctor.

Storage
  • Store at room temperature below 86 degrees F (30 degrees C) away from light and moisture.
  • Do not store in the bathroom.
  • Keep all medications away from children and pets.

Overdose
  • Symptoms of overdose may include: slow/shallow breathing, extreme weakness, loss of consciousness.

How To Use
  • Take this medication by mouth with or without food, usually 4 times a day (every 6 hours) or as directed by your doctor.This medication is usually started in the hospital.
  • Your doctor may change your dose frequently at first to find the best dose for you.
  • Dosage is based on your medical condition and response to therapy (e.g., cortisol blood levels).Use this medication regularly to get the most benefit from it.
  • To help you remember, take it at the same times each day.Do not stop taking this medication without consulting your doctor.
  • Some conditions may become worse when this drug is suddenly stopped.
  • Your dose may need to be gradually decreased.Inform your doctor if your condition persists or worsens.

Side Effects
  • Drowsiness, dizziness, headache, nausea, vomiting, or loss of appetite may occur.
  • If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: cold intolerance, constipation, fainting, slow/fast heartbeat, tiredness, weakness, weight gain.Tell your doctor immediately if any of these rare but very serious side effects occur: easy bleeding/bruising, unwanted facial/body hair.This medication can lower the body's ability to fight an infection.
  • Notify your doctor promptly if you develop any signs of an infection such as fever, chills, or persistent sore throat.Aminoglutethimide can commonly cause a rash that usually goes away.
  • However, you may not be able to tell it apart from a rash that could be a sign of a severe reaction.
  • Therefore, seek immediate medical attention if you develop a rash.A very serious allergic reaction to this drug is rare.
  • However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions
  • Before taking aminoglutethimide, tell your doctor or pharmacist if you are allergic to it; or to glutethimide; or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: current infection (especially viral infections such as chickenpox, herpes), kidney disease, liver disease, low blood pressure, underactive thyroid (hypothyroidism).This drug may make you dizzy or drowsy.
  • Use caution while driving, using machinery, or doing any activity that requires alertness.
  • Limit alcoholic beverages.This medication can make it difficult to control your blood pressure.
  • To minimize dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.If you have been using this product, your body may not produce enough natural steroids.
  • You may need to start taking additional corticosteroids (e.g., hydrocortisone), especially if your body is stressed due to a major infection, surgery or injury.
  • Tell your doctor immediately if any of the following side effects occur: unusual weakness, sudden weight loss, dizziness.
  • Carry a warning card or medical ID bracelet that identifies your need for oral corticosteroids during times of stress.
  • Consult your doctor or pharmacist for more details.Before having surgery, tell your doctor or dentist that you are using this medication.This medication is not recommended for use during pregnancy.
  • It may harm an unborn baby.
  • Discuss the risks and benefits with your doctor.It is not known if this drug passes into breast milk and could have undesirable effects on a nursing infant.
  • Therefore, breast-feeding is not recommended while using this drug.
  • Consult your doctor before breast-feeding.

Missed Dose
  • If you miss a dose, take it as soon as you remember.
  • If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.
  • Do not double the dose to catch up.

Drug Interactions
  • Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them.
  • Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: "blood thinners" (e.g., warfarin), dexamethasone, medroxyprogesterone, theophylline, "water pills"/diuretics (e.g., furosemide).Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-seizure drugs (e.g., carbamazepine), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., chlorpromazine, risperidone, amitriptyline, trazodone).Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients.
  • Ask your pharmacist about using those products safely.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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