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Drug Guide    A   Altexide

  Prescription drug information   Post your opinion about this drug  

   Altexide

Altexide
Oral


This product is used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This product is also used to treat swelling/water retention (edema), which can result from conditions such as heart failure, severe liver disease, or severe kidney disease. Reducing swelling/water retention can help to improve symptoms such as trouble breathing.This product contains two medications, spironolactone and hydrochlorothiazide. Both are water pills (diuretics) that work by increasing the amount of urine that you make. This causes your body to get rid of extra salt and water, which is thought to help relax the blood vessels so that blood can flow more easily. Spironolactone also blocks the activity of a certain natural substance made by your body (aldosterone) that may contribute to swelling/fluid retention in certain conditions.

 
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 Altexide images:

OverviewPhotosHow To UseSide EffectsPrecautionsMissed DoseDrug Interactions
Altexide

Uses
This product is used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This product is also used to treat swelling/water retention (edema), which can result from conditions such as heart failure, severe liver disease, or severe kidney disease. Reducing swelling/water retention can help to improve symptoms such as trouble breathing.This product contains two medications, spironolactone and hydrochlorothiazide. Both are water pills (diuretics) that work by increasing the amount of urine that you make. This causes your body to get rid of extra salt and water, which is thought to help relax the blood vessels so that blood can flow more easily. Spironolactone also blocks the activity of a certain natural substance made by your body (aldosterone) that may contribute to swelling/fluid retention in certain conditions.
Notes
  • Do not share this medication with others.Lifestyle changes such as stress reduction programs, exercise, and dietary changes may increase the effectiveness of this medicine.
  • Talk to your doctor or pharmacist about lifestyle changes that might benefit you.Laboratory and/or medical tests (e.g., liver function tests, blood salt levels, complete blood counts) should be performed regularly to monitor your progress or check for side effects.
  • Consult your doctor for more details.Have your blood pressure and heart rate checked regularly while taking this medication.
  • Learn how to monitor your own blood pressure and heart rate at home, and share the readings with your doctor.

Storage
  • Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture.
  • Do not store in the bathroom.
  • Keep all medicines away from children and pets.

Overdose
  • Symptoms of overdose may include fainting, severe weakness, decrease in the amount of urine, slow/shallow breathing.

How To Use
  • See also the Warning and Drug Interactions sections.Take this medication by mouth, usually once daily or as directed by your doctor.
  • If stomach upset occurs, you may take it with food or milk.It is best to take the last dose of this medication early in the day (before 4-6 PM) to avoid having to get up during the night to urinate.
  • Consult your doctor or pharmacist if you have questions about your dosing schedule.The dosage is based on your age, medical condition and response to therapy.
  • If you have severe liver or kidney problems, your dosage may need to be adjusted.Cholestyramine and colestipol may decrease the absorption of this medication.
  • If you are taking either of these drugs, separate them from this medication by at least 4 hours.Use this medication regularly in order to get the most benefit from it.
  • To help you remember, take it at the same time each day.
  • It is important to continue taking this medication even if you feel well.
  • Most people with high blood pressure do not feel sick.
  • It may take up to several weeks before the full benefit of this drug takes effect.Do not stop taking this medication without first consulting your doctor.
  • Some conditions may become worse when the drug is abruptly stopped.
  • Your dose may need to be gradually decreased.Inform your doctor if your condition worsens (e.g., your routine blood pressure readings increase).

Side Effects
  • Dizziness, lightheadedness, tiredness and blurred vision may occur as your body adjusts to the medication.
  • You may also be more sensitive to sunburn (see Precautions section).
  • Nausea, stomach upset, headache and restlessness may also occur.
  • If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.This medication may cause too much body water and salts to be lost (dehydration).
  • Tell your doctor immediately if you have any of these unlikely but serious symptoms of dehydration: very dry mouth, thirst, muscle cramps, weakness, fast heartbeat, vomiting, severe dizziness, confusion, unusual decrease in the amount of urine, fainting, seizures.This medication may lead to high levels of potassium.
  • This can lead to serious (rarely fatal) heart rhythm problems.
  • If you notice any of the following unlikely but serious side effects, seek immediate medical attention: severe muscle weakness, cold sweats, irregular breathing, fast/weak heartbeats, tingling of the hands/feet.Tell your doctor immediately if any of these unlikely but serious side effects occur: worsening of gout, flushing, unusual tiredness, mental/mood changes (e.g., depression), rapid breathing, changes in the timing of the menstrual cycle, decreased sexual ability, enlargement of breasts in men, vision changes (yellow vision).Tell your doctor immediately if any of these rare but very serious side effects occur: easy bruising/bleeding, signs of infection (e.g., fever, persistent sore throat), yellowing of the eyes/skin, persistent nausea/vomiting, severe stomach/abdominal pain, dark urine, slurred speech, black stools, persistent rectal bleeding, painful erections (Peyronie's disease).A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs.
  • Symptoms of a serious allergic reaction may include: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions
  • Before taking this product, tell your doctor or pharmacist if you are allergic to either spironolactone or hydrochlorothiazide; or to other thiazide diuretics (e.g., polythiazide); or to other sulfa drugs (e.g., sulfamethoxazole); or if you have any other allergies.This medication should not be used if you have certain medical conditions.
  • Before using this medicine, consult your doctor or pharmacist if you have: an inability to make urine (anuria), other severe kidney problems (e.g., acute renal failure), high potassium levels (hyperkalemia), severe liver disease.Before using this medication, tell your doctor or pharmacist your medical history, especially of: mild to moderate liver disease, severe kidney disease, asthma, certain immune system problems (lupus), diabetes, gout, parathyroid problems (hyperparathyroidism), high levels of fats in the blood (cholesterol or triglycerides), low salts in the blood (e.g., low sodium, potassium, calcium), loss of too much body water (dehydration), recent nerve surgery (e.g., sympathectomy).Before having surgery, tell your doctor or dentist that you are taking this medication.This drug may make you dizzy or drowsy; use caution while engaging in activities requiring alertness such as driving or using machinery.
  • Limit alcoholic beverages.To reduce dizziness and lightheadedness, get up slowly when rising from a sitting or lying position, and drink plenty of fluids.
  • Too much sweating, diarrhea or vomiting may cause you to lose large amounts of water and salts, causing lightheadedness.
  • Avoid heavy exercise.
  • Report prolonged diarrhea or vomiting to your doctor.Caution is advised when using this drug in the elderly because they may be more sensitive to its effects, especially dizziness and lightheadedness.This medication may make you more sensitive to the sun.
  • Avoid prolonged sun exposure, tanning booths, and sunlamps.
  • Use a sunscreen and wear protective clothing when outdoors.If you have diabetes, this product may make it harder to control your blood sugar levels.
  • Check your blood sugar levels regularly as directed by your doctor.
  • Tell your doctor immediately if you have symptoms of high blood sugar such as increased thirst and urination.
  • Your anti-diabetic medication or diet may need to be adjusted.This product should be used only when clearly needed during pregnancy.
  • Babies born to mothers who have taken this medication during pregnancy may be at risk for liver problems and bleeding problems.
  • Discuss the risks and benefits with your doctor.Both hydrochlorothiazide and spironolactone pass into breast milk.
  • Breast-feeding while using this medication is not recommended.
  • Consult your doctor before breast-feeding.

Missed Dose
  • If you miss a dose, take it as soon as you remember.
  • If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.
  • Do not double the dose to catch up.

Drug Interactions
  • See also How to Use section.Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it.
  • Do not start, stop, or change the dosage of any medicine before checking with them first.This drug should not be used with the following medications because very serious interactions may occur: dofetilide, tacrolimus.If you are currently using any of these medications, tell your doctor or pharmacist before starting spironolactone with hydrochlorothiazide.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: alcohol, barbiturates (e.g., phenobarbital), cisapride, diazoxide, digoxin, drugs for diabetes (e.g., glyburide, insulin), certain hormones (ACTH), lithium, mitotane, narcotic pain relievers (e.g., codeine), norepinephrine, skeletal muscle relaxants (e.g., tubocurarine), drugs that cause potassium loss (e.g., amphotericin B, corticotropin, corticosteroids including prednisone), drugs whose removal from the body is affected by the acid level in urine (e.g., amphetamine, methenamine).This medication may increase your potassium levels.
  • Using this product with other medications that increase your potassium levels may cause very serious (possibly fatal) side effects.
  • These medications include: ACE inhibitors (e.g., captopril, enalapril), ARBs (e.g., candesartan, losartan), drospirenone, eplerenone, nonsteroidal anti-inflammatory drugs (NSAIDs such as ibuprofen, indomethacin, naproxen), other water pills that may increase your potassium level, including amiloride, potassium-containing products (e.g., salt substitutes), potassium supplements.Limit foods high in potassium such as bananas, potatoes, cantaloupe, citrus fruits, dates, prunes, avocado, raisins, cooked spinach, lentils and low-salt milk.
  • These foods may increase your potassium levels if eaten in large amounts.
  • Discuss with your doctor or nutritionist.Check the labels on all your medicines (e.g., cough-and-cold products, diet aids, aspirin, nonsteroidal anti-inflammatory drugs-NSAIDs for pain/fever reduction) because they may contain ingredients that could increase your blood pressure or cause a fast heartbeat (e.g., pseudoephedrine, phenylephrine, chlorpheniramine, diphenhydramine, clemastine, ibuprofen, naproxen).
  • Ask your pharmacist about the safe use of those products.This product can affect the results of certain lab tests (parathyroid function, urine and blood steroids).
  • Make sure laboratory personnel and all your doctors know you use this drug.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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