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Ketoprofen is used to reduce pain, swelling, and joint stiffness from arthritis. It is also used to relieve mild to moderate pain such as menstrual cramps, headaches, muscle aches, backaches, and dental pain. In addition, ketoprofen is used to reduce fever and to relieve minor aches and pains due to the common cold or flu. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID).

 
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OverviewPhotosHow To UseSide EffectsPrecautionsMissed DoseDrug Interactions
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Uses
Ketoprofen is used to reduce pain, swelling, and joint stiffness from arthritis. It is also used to relieve mild to moderate pain such as menstrual cramps, headaches, muscle aches, backaches, and dental pain. In addition, ketoprofen is used to reduce fever and to relieve minor aches and pains due to the common cold or flu. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID).
Notes
  • Do not share this medication with others.Laboratory and/or medical tests (e.g., complete blood count, liver and kidney function tests) may be performed periodically to monitor your progress or check for side effects.
  • Consult your doctor for more details.Non-drug treatment for arthritis as approved by your doctor (e.g., weight loss if needed, strengthening and conditioning exercises) may help improve your flexibility, range of motion, and joint function.
  • Consult your doctor for specific instructions.

Storage
  • Store at controlled room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture.
  • Avoid excessive heat.
  • Do not store in the bathroom.
  • Keep all medicines away from children and pets.

Overdose
  • Symptoms of overdose may include: severe stomach pain, vomit that looks like coffee grounds, extreme drowsiness, loss of consciousness, slowed or shallow breathing, seizures.

How To Use
  • Read the Medication Guide provided by your pharmacist before you start using ketoprofen and each time you get a refill.
  • If you have any questions regarding the information, consult your doctor or pharmacist.Take this medication by mouth with a full glass of water (8 ounces or 240 milliliters), unless your doctor directs you otherwise.
  • Do not lie down for at least 30 minutes after taking this drug.If stomach upset occurs while taking this medication, take it with food, milk, or an antacid.
  • The dosage is based on your medical condition and response to therapy.
  • Do not increase your dose or take it more frequently than recommended because this may increase your risk of stomach bleeding.
  • Do not take more than 100 mg daily if you have severe kidney disease.
  • The smallest effective dose should be used.
  • Consult your doctor or pharmacist for more information.If you are using this medication to relieve arthritis, take it usually 3 or 4 times a day on a regular schedule, or as directed by your doctor.If you are using ketoprofen on an "as needed" basis (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur.
  • If you wait until the pain has significantly worsened, the medicine may not work as well.
  • If repeat doses are needed, they can be taken usually 6 or 8 hours apart, or as directed by your doctor.If you use this medication for migraine headache, and the pain is not relieved or worsens after the first dose, tell your doctor immediately.For nonprescription ketoprofen products: Follow the package instructions.
  • Consult your doctor before taking this medication if the painful area is red or swollen.
  • Consult your doctor immediately if fever or pain do not improve within 24 hours, worsen or last for more than 3 days, or if new symptoms appear.
  • In general, do not take more than 2 tablets (25 milligrams) in a 4-6 hour period or 6 tablets (75 milligrams) in a 24 hour period.
  • Do not use in children less than 16 years old unless so directed by the doctor.In certain conditions (e.g., arthritis), it may take up to 2-4 weeks, taken regularly, before the full benefits of this drug take effect.Inform your doctor if your condition persists or worsens.

Side Effects
  • Stomach upset, gas, constipation, diarrhea, nausea, vomiting, dizziness, drowsiness, or headache may occur.
  • If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: stomach pain, swelling of the hands or feet, sudden or unexplained weight gain, vision changes, hearing changes (e.g., ringing in the ears), mental/mood changes, fast/pounding heartbeat, persistent/severe headache, fainting, difficult/painful swallowing.Tell your doctor immediately if any of these rare but very serious side effects occur: change in the amount of urine, easy bruising/bleeding, signs of infection (e.g., fever, persistent sore throat), unexplained stiff neck.This drug may rarely cause serious (possibly fatal) liver disease.
  • If you notice any of the following highly unlikely but very serious side effects, stop taking ketoprofen and consult your doctor or pharmacist immediately: yellowing eyes or skin, dark urine, unusual/extreme tiredness, severe stomach/abdominal pain, persistent nausea/vomiting.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs.
  • Symptoms of a serious allergic reaction may include: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions
  • Before taking ketoprofen, tell your doctor or pharmacist if you are allergic to it; or to aspirin, other NSAIDs (e.g., ibuprofen, naproxen, celecoxib), or tartrazine yellow dye; or if you have any other allergies.This medication should not be used if you have certain medical conditions.
  • Before using this medicine, consult your doctor or pharmacist if you have: aspirin-sensitive asthma (a history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDs), recent heart bypass surgery (CABG).Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, poorly controlled diabetes, stomach/intestinal problems/esophagus (e.g., recurring heartburn/stomach pain, bleeding, ulcers), heart disease (e.g., congestive heart failure, history of heart attack), high blood pressure, stroke, swelling (edema, fluid retention), dehydration, blood disorders (e.g., anemia), bleeding or clotting problems, asthma, growths in the nose (nasal polyps).Before having surgery, tell your doctor or dentist that you are taking this medication.This drug may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery.This medicine may cause stomach bleeding.
  • Daily use of alcohol and tobacco, especially when combined with this medicine, may increase your risk for stomach bleeding.
  • Limit alcohol and stop smoking.
  • Before taking the nonprescription product, the manufacturer recommends that you consult your doctor if you drink 3 or more alcoholic beverages daily.
  • Consult your doctor or pharmacist for more information.This medication may make you more sensitive to the sun.
  • Avoid prolonged sun exposure, tanning booths or sunlamps.
  • Use a sunscreen and wear protective clothing when outdoors.Caution is advised when using this drug in the elderly because they may be more sensitive to the side effects of the drug, especially stomach bleeding and kidney effects.This medication should be used only when clearly needed during the first 6 months of pregnancy.
  • It is not recommended for use during the last 3 months of pregnancy due to possible harm to an unborn baby and interference with normal labor/delivery.
  • Discuss the risks and benefits with your doctor.It is not known if this drug passes into breast milk.
  • Breast-feeding while using this drug is not recommended.
  • Consult your doctor before breast-feeding.

Missed Dose
  • If you are prescribed this drug on a regular schedule (not just "as needed") and you miss a dose, take it as soon as you remember.
  • If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.
  • Do not double the dose to catch up.

Drug Interactions
  • Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it.
  • Do not start, stop, or change the dosage of any medicine before checking with them first.This drug should not be used with the following medications because very serious interactions may occur: cidofovir, ketorolac.If you are currently using any of these medications, tell your doctor or pharmacist before starting ketoprofen.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: anti-platelet drugs (e.g., cilostazol, clopidogrel), oral bisphosphonates (e.g., alendronate), "blood thinners" (e.g., enoxaparin, heparin, warfarin), corticosteroids (e.g., prednisone), cyclosporine, high blood pressure drugs (including ACE inhibitors such as captopril, angiotensin II receptor antagonists such as losartan, and beta-blockers such as metoprolol), lithium, methotrexate, pemetrexed, probenecid, SSRI antidepressants (e.g., fluoxetine, sertraline), "water pills" (diuretics such as furosemide, hydrochlorothiazide, triamterene).Check all prescription and nonprescription medicine labels carefully for other pain/fever drugs (NSAIDs such as aspirin, celecoxib, ibuprofen).
  • These drugs are similar to this medication, so taking one of these drugs while also taking this medication may increase your risk of side effects.
  • However, if your doctor has prescribed low doses of aspirin to prevent heart attack or stroke (usually at dosages of 81-325 milligrams a day), you should continue to take the aspirin.
  • Daily use of NSAIDs (e.g., ibuprofen) may decrease aspirin's ability to prevent heart attack/stroke.
  • Consult your doctor or pharmacist for more details and to discuss other possible treatments (e.g., acetaminophen) for your pain/fever.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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