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Drug Guide    A   APOKYN SubQ

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This medication is used to treat the symptoms of Parkinson's disease. It can improve your ability to move during frequent "off" periods. It can decrease shakiness (tremor), stiffness, slowed movement, and unsteadiness. This medication is thought to work by helping to restore the balance of a certain natural substance (dopamine) in the brain.Apomorphine is used to treat "off" episodes when they occur. It is not used to prevent "off" episodes. This drug should not be used instead of your usual medications for Parkinson's disease. Continue taking all your medications as directed by your doctor.

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 APOKYN SubQ images:

OverviewPhotosHow To UseSide EffectsPrecautionsMissed DoseDrug Interactions

This medication is used to treat the symptoms of Parkinson's disease. It can improve your ability to move during frequent "off" periods. It can decrease shakiness (tremor), stiffness, slowed movement, and unsteadiness. This medication is thought to work by helping to restore the balance of a certain natural substance (dopamine) in the brain.Apomorphine is used to treat "off" episodes when they occur. It is not used to prevent "off" episodes. This drug should not be used instead of your usual medications for Parkinson's disease. Continue taking all your medications as directed by your doctor.
  • Do not share this medication with others.

  • Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture.
  • Brief storage between 59-86 degrees F (15-30 degrees C) is permitted.
  • Do not store in the bathroom.
  • Keep all medicines away from children and pets.Syringes can be filled the night before use and stored in the refrigerator until the next day.
  • Discard this type of pre-filled syringe if not used in 24 hours.

  • Symptoms of overdose may include: very severe nausea/vomiting, loss of consciousness.

How To Use
  • Read the Patient Information Leaflet provided by your pharmacist before you start using apomorphine and each time you get a refill.
  • If you have any questions, consult your doctor or pharmacist.Learn all preparation and usage instructions in the product package.
  • If any of the information is unclear, consult your doctor or pharmacist.Before using, check this product visually for particles or discoloration.
  • If either is present, do not use the liquid.
  • Check the dose carefully before injecting.
  • Apomorphine is given by the milliliter, not by the milligram.
  • There are 10 milligrams of drug in each milliliter of this liquid, so if the wrong measuring unit is used, you may accidentally inject 10 times the amount of drug you need.
  • Be sure you have the correct dose to prevent accidental overdose.
  • If you are not sure how to measure your dose correctly, consult your pharmacist before injecting.If you are using the prefilled cartridge/pen, keep track of the doses used to make sure there is enough medication left in the device to give you a full dose.Clean the injection site before injecting.
  • Inject this medication under the skin as needed to treat decreased/frozen muscle movement ("off" episode) as directed by your doctor.
  • You may need to use this medication several times a day.
  • Do not use a second injection for the same "off" episode.
  • Wait at least 2 hours between injections.Do not inject this medication into a vein.
  • It is important to change the location of the injection site with each dose to avoid problem areas under the skin.
  • Therefore, choose a different injection site with each dose.
  • The abdomen, thighs, and upper arms are recommended sites for the injection.
  • Do not inject into skin that is irritated, sore, or infected.
  • Learn how to store and discard needles and medical supplies safely.
  • Never reuse syringes or needles.
  • Consult your pharmacist for details.Dosage is based on your medical condition and response to treatment.
  • To decrease the risk of side effects (e.g., nausea, drowsiness, low blood pressure) when you first start using apomorphine, your doctor will slowly increase your dosage until the best dose for you is reached.
  • Your doctor will usually have you use the first dose in the office where your blood pressure can be checked and you can be watched for side effects.
  • A health care professional will also teach you to inject this medication correctly.
  • Nausea is very common with this medication.
  • To decrease the risk of nausea, your doctor may direct you to start taking another medication (e.g., trimethobenzamide) 3 days before your first dose of apomorphine and to continue taking it for at least 2 months.Use this medication as prescribed.
  • If you stop using this medication for longer than 1 week, you may need to increase your dose slowly back to your previous dosage.
  • Talk with your doctor about how to restart the medication.
  • Do not stop using this medication without your doctor's approval.
  • If you have been using this medication frequently and suddenly stop using this drug, withdrawal reactions may occur.
  • Such reactions can include fever, muscle stiffness, and confusion.
  • Report any such reactions to your doctor immediately.Rarely, abnormal drug-seeking behavior (drug abuse) is possible with this medication.
  • Do not increase your dose or use it more frequently than prescribed.
  • Properly stop the medication when so directed.Tell your doctor if your condition persists or worsens.

Side Effects
  • Redness/swelling/pain/itching at the injection site, nausea, vomiting, headache, sweating, dizziness, drowsiness, yawning, or runny nose may occur.
  • If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: fainting, uncontrolled movements, mental/mood changes (e.g., depression, hallucinations, trouble sleeping), muscle cramps/spasm, swelling of the hands/legs/ankles/feet.Seek immediate medical attention if any of these rare but very serious side effects occur: chest pain, shortness of breath, unusually fast/pounding/irregular heartbeat, slurred speech, vision changes, weakness on one side of the body.Some people using apomorphine have reported falling asleep suddenly during their usual daily activities (e.g., talking on the phone, driving).
  • In some cases, sleep occurred without any feelings of drowsiness beforehand.
  • This sleep effect may occur any time during treatment.
  • Therefore, you should not drive or take part in other possibly dangerous activities until you are certain that this medication will not cause drowsiness or sudden sleep.
  • If you experience increased sleepiness or fall asleep during the day, do not drive or take part in other possibly dangerous activities until you have discussed this effect with your doctor.
  • Your risk is increased with use of alcohol or other medications that can make you drowsy.You may also develop a sudden drop in blood pressure that can cause dizziness, nausea, and fainting.
  • This effect may also increase your risk of a fall.
  • This drop in blood pressure is more likely when you are first starting the medication, when your dose is increased, or when you get up suddenly.
  • To lower your risk, get up slowly from a sitting or lying position.
  • Avoid alcohol.For males, in the very unlikely event you have a painful, prolonged erection (lasting more than 4 hours), stop using this drug and seek immediate medical attention, or permanent problems could occur.A very serious allergic reaction to this drug is rare.
  • However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching, swelling, severe dizziness, trouble breathing.If you notice other effects not listed above, contact your doctor or pharmacist.

  • Before using apomorphine, tell your doctor or pharmacist if you are allergic to it; or to sulfites; or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma, heart problems (e.g., chest pain, heart attack), slow/fast/irregular heartbeat (e.g., arrhythmia, prolonged QT interval), mental/mood disorders (e.g., confusion, hallucinations, psychosis, schizophrenia), kidney problems, liver problems, symptoms of low blood pressure (e.g., dizziness, fainting), low levels of magnesium/potassium in the blood, sleep disorder (e.g., sleep apnea, narcolepsy), stroke or other brain problem.This drug may make you dizzy or drowsy.
  • Use caution while driving, using machinery, or doing any activity that requires alertness.
  • Avoid alcoholic beverages.Caution should be taken when using this drug in the elderly because they may be at greater risk for certain side effects such as falls and hallucinations.During pregnancy, this medication should be used only when clearly needed.
  • Discuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milk.
  • Therefore, breast-feeding while using this medication is not recommended.
  • Consult your doctor before breast-feeding.

Missed Dose
  • Not applicable.

Drug Interactions
  • Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them.
  • Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.This drug should not be used with the following medications because very serious interactions may occur: certain drugs for nausea/bowel problems (5HT-3 antagonists such as alosetron, granisetron, ondansetron).If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting apomorphine.Apomorphine may affect the heartbeat when used at higher doses.
  • Other drugs besides apomorphine may affect the heartbeat (QTc prolongation in the EKG).
  • They include amiodarone, dofetilide, pimozide, quinidine, sotalol, procainamide, and erythromycin, among others.
  • QTc prolongation can infrequently result in a serious (rarely fatal) irregular heartbeat.
  • If you are taking any of these medications, consult your doctor or pharmacist for more details and for instructions on how you may reduce your risk of this effect.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: antipsychotics (e.g., chlorpromazine, haloperidol, thiothixene), certain drugs for nausea (e.g., metoclopramide, phenothiazines such as prochlorperazine), drugs for high blood pressure (e.g., beta blockers such as atenolol), vasodilators (e.g., nitrates), "water pills" (diuretics such as furosemide, thiazides).Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-seizure drugs (e.g., carbamazepine), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., risperidone, amitriptyline, trazodone).
  • Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain ingredients that cause drowsiness.
  • Ask your pharmacist about using those products safely.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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